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This is really more of a tool that allows researchers to take protein sequences and get pretty good predictions of what the crystallized protein will look like.
by photochemsyn 4y ago
This is really more of a tool that allows researchers to take protein sequences and get pretty good predictions of what the crystallized protein will look like. It might be an aid to crystallization as well as you can look at crystallization conditions of similar proteins. However, claims that real-world data is no longer needed are certainly overblown.
Another issue is that a complete analysis of a protein's function, particularly catalytic proteins, requuires that you understand their dynamics, which are not reflected in static protein crystals. Other methods like NMR are used for that purpose.