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Growing high quality crystals of Organometallic compounds is easier than many other disciplines in chemistry, orders of magnitude easier than proteins, as an co

• COGlory 4y ago
  Depends. A random metallo-organic compound vs a random protein? Yes. But the problem can be further up the chain. Synthesis can be expensive and difficult, and you need a relatively large crystal (at least for X-ray). If you have low symmetry, you need several relatively large crystals all of which need to collect enough data before they die to integrate across the datasets. It typically isn't thought to be as challenging, but it can be.
  • muaytimbo 4y ago
    In my experience it's always been easier both growing and solving organometallic compounds. Borrowing the phase from previously solved structures is trivial for organometallic compounds which simplifies the density modeling while the fact that most organometallic compounds lack the chirality found in every protein generally means they pack into higher symmetry groups facilitating the growth of larger high quality crystals.