3 ms·

Meh. Scalp advancement works pretty well. That is removing a strip of skin on the forehead and then pulling the rest down. It's adding a massive amount of tensi

Meh. Scalp advancement works pretty well. That is removing a strip of skin on the forehead and then pulling the rest down. It's adding a massive amount of tension in a very short period of time. If this resulted in more hair loss, nobody would be doing this procedure. More evidence in favor of androgens being the cause is the ridiculous recovery that some transgender women experience in hair regrowth after starting HRT. Sometimes it's slick bald to nearly a full head of hair. There was also a guy who isn't trans on some hair loss forum who decided to take the strongest antiandrogens he could order plus some estrogen and had incredible regrowth. Utimately it's probably multifactorial. Minoxidil helps, and that seems to be more about blood flow than androgens, though it's not totally clear why it works.

rantallion 4y ago
> Minoxidil helps, and that seems to be more about blood flow than androgens, though it's not totally clear why it works. Isn't one of the causes of hair loss a build-up of dihydrotestosterone in the scalp? Improving blood flow possibly allows for more to be carried away instead of deposited.
- stubybubs 4y ago
  Could be part of it. Minoxdil is just one kind of vasodilator. There hasn't been regrowth noticed with other classes like ACE inhibitors. And in general cardio training hasn't been shown to improve hair loss. Minoxidil might induce vascular endothelial growth factor as well. Maybe you need both? It also seems to work much better in combination with finasteride or dutasteride. All medicine is a little human experimentation. We don't even understand the complete mechanism of action of acetaminophen and that drug has been around for over 130 years. Generally if something works, we're happy.
Traubenfuchs 4y ago
Minoxidils modes of action are actually incredibly multifaceted. It‘s not limited at all to messing with the blood flow. The wikipedia article enumerates all the different things it does and how they could relate to hair growth.

rantallion 4y ago

> Minoxidil helps, and that seems to be more about blood flow than androgens, though it's not totally clear why it works. Isn't one of the causes of hair loss a build-up of dihydrotestosterone in the scalp? Improving blood flow possibly allows for more to be carried away instead of deposited.

stubybubs 4y ago
Could be part of it. Minoxdil is just one kind of vasodilator. There hasn't been regrowth noticed with other classes like ACE inhibitors. And in general cardio training hasn't been shown to improve hair loss. Minoxidil might induce vascular endothelial growth factor as well. Maybe you need both? It also seems to work much better in combination with finasteride or dutasteride. All medicine is a little human experimentation. We don't even understand the complete mechanism of action of acetaminophen and that drug has been around for over 130 years. Generally if something works, we're happy.

Traubenfuchs 4y ago

Minoxidils modes of action are actually incredibly multifaceted. It‘s not limited at all to messing with the blood flow. The wikipedia article enumerates all the different things it does and how they could relate to hair growth.