Back in the day ('70s and '80s i think), trans women used to take synthetic estrogens (such as premarin, IIRC was the drug of choice) before switching to bioide

Back in the day ('70s and '80s i think), trans women used to take synthetic estrogens (such as premarin, IIRC was the drug of choice) before switching to bioidentical estrogen from estradiol tablets in the '90s and '00s, I think because bioidentical E is seen as more effective with a softer side effect profile than the synthetics, in particular bioidentical doesn't hurt the liver as much. Drinking horse piss in the 70s sure was metal though. ("pre-mar-in" = "pregnant mare urine," a source of estrogen since 1930). (folk knowledge and personal anecdata)