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Trans women typically take E2 (bioidentical estrogen), not EE2. EE2 is 100 times more potent than E2 for certain endocrine interactions. Unlike E2, EE2 is not a
by elil17 4y ago
Trans women typically take E2 (bioidentical estrogen), not EE2. EE2 is 100 times more potent than E2 for certain endocrine interactions. Unlike E2, EE2 is not a naturally occurring hormone. E2 causes female puberty when administered to males (except for menstruation), but EE2 isn’t necessarily going to do the same thing because it is a different molecule. While worrying about “feminizing” is probably hype, worrying about possible effects such as infertility seems totally reasonable.
- marricks 4y agoThank you for the correction!
- gcr 4y agoBack in the day ('70s and '80s i think), trans women used to take synthetic estrogens (such as premarin, IIRC was the drug of choice) before switching to bioidentical estrogen from estradiol tablets in the '90s and '00s, I think because bioidentical E is seen as more effective with a softer side effect profile than the synthetics, in particular bioidentical doesn't hurt the liver as much. Drinking horse piss in the 70s sure was metal though. ("pre-mar-in" = "pregnant mare urine," a source of estrogen since 1930). (folk knowledge and personal anecdata)
- elil17 4y agoPermarin was made into pills, not drank directly. Permarin is a conjugate estrogen (mix of natural estrogens). It had a higher risk of blood clots than pure E2. However it was not EE2.
- sudosysgen 4y agoIt's still not that bad though, because the math is off. 4 ng is about 250,000x less than the smallest E2 dose a trans woman would take, and 2 million times less than the strongest doses some take.
- deleted 4y ago[deleted]