10 ms·

I think it's also worth bearing in mind that œstradiol is not some exclusively “female” hormone: cis men have it in their blood too, just at a lower concentrati

I think it's also worth bearing in mind that œstradiol is not some exclusively “female” hormone: cis men have it in their blood too, just at a lower concentration. In fact, without it, males are infertile!

bergenty 4y ago
Sure but when you’re talking about order of magnitude differences there is a clear delineation and the fear is not unwarranted.
- connicpu 4y ago
  The normal levels are closer then you think. The exact numbers differ depending on what lab you ask, but the normal male range of estradiol in the blood is around 15-55 pg/mL, while the normal healthy female level can vary from 70-500 pg/mL depending on the current stage of the menstrual cycle. Normally that doesn't matter though as most of estradiol's effects are overridden by an overwhelming amount of testosterone
  - bergenty 4y ago
    Yes but when the overwhelming majority of women are at >400 pg/ml and men under 20 pg/ml it’s more than an order of magnitude change.
teslabox 4y ago
Estrogen is a 'stress hormone' that needs to be balanced with anti-stress hormones for optimal health. All the steroids in the body are made from cholesterol. The term is steroidogenesis: https://en.wikipedia.org/wiki/Steroid#Steroidogenesis https://en.wikipedia.org/wiki/Steroid#Steroidogenesis Estrogen is at the end of the steroidogenesis pathway. It's a stress hormone. In the menstrual cycle, estrogen tells the uterine lining to 'swell and divide'. Fertile women are protected from their higher estrogen levels by their high levels of Progesterone USP during the luteal phase of their menstrual cycle. When women reach menopause, their heart attack numbers rapidly reach men's heart attack numbers. Adipose tissue has a lot of the aromatase enzyme [0], which converts testosterone to estrogen. People with more adipose tissue lose their testosterone by converting it to estrogen. The heart of both genders concentrates testosterone. [0] https://en.wikipedia.org/wiki/Aromatase https://en.wikipedia.org/wiki/Aromatase [1] Obesity, estrogens and adipose tissue dysfunction – implications for pulmonary arterial hypertension - https://journals.sagepub.com/doi/full/10.1177/2045894020952023 https://journals.sagepub.com/doi/full/10.1177/20458940209520... I sold a progesterone supplement on Amazon years ago... My best customer was "Billie", who I suspect was MTF and was using progesterone USP to balance his estrogen treatments. I referred him to other manufacturers when he noticed my supplement was no longer available. Pregnenolone is a useful supplement for balancing the steroid system: https://en.wikipedia.org/wiki/Steroid#/media/File:Steroidogenesis.svg https://en.wikipedia.org/wiki/Steroid#/media/File:Steroidoge... (edit: added [1])

bergenty 4y ago

Sure but when you’re talking about order of magnitude differences there is a clear delineation and the fear is not unwarranted.

connicpu 4y ago
The normal levels are closer then you think. The exact numbers differ depending on what lab you ask, but the normal male range of estradiol in the blood is around 15-55 pg/mL, while the normal healthy female level can vary from 70-500 pg/mL depending on the current stage of the menstrual cycle. Normally that doesn't matter though as most of estradiol's effects are overridden by an overwhelming amount of testosterone
- bergenty 4y ago
  Yes but when the overwhelming majority of women are at >400 pg/ml and men under 20 pg/ml it’s more than an order of magnitude change.

teslabox 4y ago

Estrogen is a 'stress hormone' that needs to be balanced with anti-stress hormones for optimal health. All the steroids in the body are made from cholesterol. The term is steroidogenesis: https://en.wikipedia.org/wiki/Steroid#Steroidogenesis https://en.wikipedia.org/wiki/Steroid#Steroidogenesis Estrogen is at the end of the steroidogenesis pathway. It's a stress hormone. In the menstrual cycle, estrogen tells the uterine lining to 'swell and divide'. Fertile women are protected from their higher estrogen levels by their high levels of Progesterone USP during the luteal phase of their menstrual cycle. When women reach menopause, their heart attack numbers rapidly reach men's heart attack numbers. Adipose tissue has a lot of the aromatase enzyme [0], which converts testosterone to estrogen. People with more adipose tissue lose their testosterone by converting it to estrogen. The heart of both genders concentrates testosterone. [0] https://en.wikipedia.org/wiki/Aromatase https://en.wikipedia.org/wiki/Aromatase [1] Obesity, estrogens and adipose tissue dysfunction – implications for pulmonary arterial hypertension - https://journals.sagepub.com/doi/full/10.1177/2045894020952023 https://journals.sagepub.com/doi/full/10.1177/20458940209520... I sold a progesterone supplement on Amazon years ago... My best customer was "Billie", who I suspect was MTF and was using progesterone USP to balance his estrogen treatments. I referred him to other manufacturers when he noticed my supplement was no longer available. Pregnenolone is a useful supplement for balancing the steroid system: https://en.wikipedia.org/wiki/Steroid#/media/File:Steroidogenesis.svg https://en.wikipedia.org/wiki/Steroid#/media/File:Steroidoge... (edit: added [1])