5 ms·
To add to this, the deep learning field has already moved on towards MSA-less structure prediction. None of this would be possible without building on top of th
by lucidrains 4y ago
To add to this, the deep learning field has already moved on towards MSA-less structure prediction. None of this would be possible without building on top of the work open sourced by Deepmind.
https://www.biorxiv.org/content/10.1101/2022.07.21.500999v1 https://www.biorxiv.org/content/10.1101/2022.07.21.500999v1
https://www.biorxiv.org/content/10.1101/2022.07.20.500902v1 https://www.biorxiv.org/content/10.1101/2022.07.20.500902v1
To be overly dismissive is to lack imagination.
- tomp 4y agoHow do we know these "MSA-less" models aren't cheating (i.e. learning all MSAs implicitly from their training data)? If they are, they would similarly fail on any "novel" AA sequence (i.e. one without known/learned MSAs)