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> It ultimately relies on mapping sequence to structure. So does every structural prediction method. > if you give it a brand new fold with no relation to oth
by flobosg 4y ago
> It ultimately relies on mapping sequence to structure.
So does every structural prediction method.
> if you give it a brand new fold with no relation to other folds, it cannot predict it
That will depend on the number of effective sequences, not the actual fold.
> I work in organisms that have virtually 0 sequence identity.
Then the problem is low sequence coverage, not the protein fold. On a side note, there are sensitive homology search protocols that rely very little on actual sequence identity.
- bamboozled 4y agoSo then based on your counter arguments to the OP, have they mapped the entire protein universe ? Or should it say, the “already known protein universe” ?
- flobosg 4y agoNeither the protein sequence nor structure spaces have been fully explored, and the sequence set of UniProt does not represent every single extant protein. My answer is “no”.