Fair point. I guess if their training data is biased towards existing known structures (via xray or nmr or whatever) then there is the risk of incorrect predict

Fair point. I guess if their training data is biased towards existing known structures (via xray or nmr or whatever) then there is the risk of incorrect predictions. At a guess, the core packing in non-globular proteins might be different? Also the distribution of secondary structure might also vary between classes. Might be worth someone studying how much structural constraints depend on fold (if they have not already).