Rather than just scrutinizing a single hypothesis for AD we must understand that it is a multi factorial disease and that there are other hypotheses as well (i

Rather than just scrutinizing a single hypothesis for AD we must understand that it is a multi factorial disease and that there are other hypotheses as well (i.e., acetylcholine, tau, transport-clearance), which affect and complicate this disease. Furthermore, we know very little about the brain, hence why novel therapies consistently fail in the clinic compared to other diseases (i.e., cancer). Most of these antibodies that target amyloid don’t even cross the blood-brain barrier (<0.1% and need an effective dose of 1000x blood-plasma for effective amyloid lowering) - provided with this, can we really attest the failure of the amyloid hypothesis? Moreover, the commenters there are big names in the AD community