So, it is back to square one. Why do depression meds work? Hypothesis A failed, move on to B. But any discussion of depression that fails to deal with it as at

So, it is back to square one. Why do depression meds work? Hypothesis A failed, move on to B. But any discussion of depression that fails to deal with it as at least a half-dozen independent illnesses, each with its own biochemical basis, is intrinsically garbage, and any conclusions bankrupt. This is why we keep seeing spurious reports that "antidepressants don't work". In every case, they take "depression" as a biochemically meaningful diagnosis of one illness, and run a RCT of medication X on a sample with illnesses A, B, C, D, E, and F. If X helps F but makes E worse, and has no effect on A-D, what will the "result" of the trial be? Garbage. "Gold-standard" garbage, if you like. GIGO. People promoting garbage results should be ashamed. Fired, too. Incompetents in medical research make things worse for us all.