4 ms·
I read that it might actually be that these specific Oligomers might not be detectable in anything but genetically engineered mice - and detection in humans has
by kamranjon 4y ago
I read that it might actually be that these specific Oligomers might not be detectable in anything but genetically engineered mice - and detection in humans has not actually been proven outside papers in question, is this true?
- pcrh 4y agoIt's quite difficult for researchers to gain access to human brains, needless to say, so the number of studies attempting to find specific oligomeric species in human brain are limited. However (and without attempting an exhaustive search), detection of oligomeric amyloid (if perhaps not the specific species reported by Lesné are reported, e.g. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1750-3639.2009.00321.x https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1750-3639....
- pessimizer 4y agoSo you're in complete agreement with the article, then? You've said nothing that wasn't mentioned.
- pcrh 4y agoHigh molecular weight assemblies of Abeta have been repeatedly identified by numerous researchers from human tissue and other sources. However, similar to myself, Derek Lowe didn't investigate the voluminous literature on the topic to see if the specific Aβ*56 species has been found in extracts of human tissue by others. With a little extra searching, I found this article below which does appear to replicate detection of a potential 56 kDa form of Aβ in human tissue by western blot of SDS-PAGE gels, as shown in the Lesné paper (Figure 1), though they express concern that its true concentrations may be very low and may be artefacts. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1582-4934.2011.01306.x https://onlinelibrary.wiley.com/doi/full/10.1111/j.1582-4934...