4 ms·
This sounds just like cholesterol to me. Yes, beta amyloids are correlated with Alzheimer’s and cholesterol is correlated to cardiac issues. But correlation is
by sudden_dystopia 4y ago
This sounds just like cholesterol to me. Yes, beta amyloids are correlated with Alzheimer’s and cholesterol is correlated to cardiac issues. But correlation is not causation. Why is their seemingly no mainstream discussion that perhaps these correlations are simply the markers of an underlying biological function that has become disregulated and leads to the presence of higher amyloid/cholesterol/etc? When we try to treat cancer, do we focus on the symptoms, or do we try to obliterate the cancer? As far as I can tell, we aren’t looking for the “cancer”, we are trying to treat symptoms.
- _Wintermute 4y ago> Why is their seemingly no mainstream discussion that perhaps these correlations are simply the markers of an underlying biological function that has become disregulated and leads to the presence of higher amyloid That's a discussion point pretty much every time the amyloid hypothesis is mentioned in the scientific literature. I'm not sure where you're going to get information about the pathophysiology of Alzheimer's disease, but it doesn't really strike me as a "mainstream" topic where they're going to discuss the finer details or debates.
- throwawaymaths 4y ago> That's a discussion point pretty much every time the amyloid hypothesis is mentioned in the scientific literature I don't feel like that's true. Back when I was a grad student doing this research it was striking to me how little that was in the literature considering how much we said it internally.