3 ms·
In the first table the "eating disorders" entry makes references to "Kleinman et al. 2015" and to "Morita et al. 2015". Neither can be found in the bibiography.
by pygy_ 4y ago
In the first table the "eating disorders" entry makes references to "Kleinman et al. 2015" and to "Morita et al. 2015". Neither can be found in the bibiography. I couldn't find a paper by some Kleinman on the topic between 2014 and 2016 (https://scholar.google.com/scholar?start=0&q=author:kleinman+anorexia&hl=fr&as_sdt=7,39&as_ylo=2014&as_yhi=2016 https://scholar.google.com/scholar?start=0&q=author:kleinman...). Morita wrote this (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145274 https://journals.plos.org/plosone/article?id=10.1371/journal...).
Neither the linked article nor Morita's mention Serguei Fetissov's pioneering work on the topic though, which is disappointing, given that he and his colleagues have long documented the link between E. Coli, the immune system and eating disorders.
The gist is that E. Coli produces a protein (CLBP) that mimics a feeding-related hormone (IIRC melanocortin). That protein ends up in the blood stream and can bind the corresponding receptors. It can also generate an immune response, and these antibodies are cross-reactive, causing autoimmunity and complicating the story.
- bluechair 4y agoDo you have any links to his work?
- pygy_ 4y agoPlucking from Google scholar you can check this https://www.pnas.org/doi/full/10.1073/pnas.222658699 https://www.pnas.org/doi/full/10.1073/pnas.222658699 and this https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/eat.22531 https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/eat.22531 among many others... https://scholar.google.com/scholar?hl=en&as_sdt=7%2C39&q=serguei+fetissov+bulimia&btnG= https://scholar.google.com/scholar?hl=en&as_sdt=7%2C39&q=ser... A key point is that the same anomalies are seen in anorexia, binge eating and bulimia.