4 ms·

Vitamin D supplementation worsens Alzheimer's progression

39 points by nojs 4y ago

gardenfelder 4y ago
New territory. Needs really deep research.
ekianjo 4y ago
In Alzheimer mice models, which are completely flawed to begin with. Another pure junk headline. They also did a retrospective population-based cohort study (no intervention), which is not enough to prove any kind of causality and is prone to confounding factors that can't be easily controlled for (how much time people spend in the sun every day will have a huge impact in their Vitamin D levels and their needs for supplementation or not).
- robwwilliams 4y ago
  You may well be right. But there are good and bad mouse models of early onset Alzheimer’s. The best is the AD-BXD mouse family model of C. Kaczorowski and colleagues. This “model” is genetically diverse—like humans.
scrollaway 4y ago
I can't possibly believe any Alzheimer's research right now. https://www.dailykos.com/stories/2022/7/22/2111914/-Two-decades-of-Alzheimer-s-research-may-be-based-on-deliberate-fraud-that-has-cost-millions-of-lives https://www.dailykos.com/stories/2022/7/22/2111914/-Two-deca... https://www.science.org/content/article/potential-fabrication-research-images-threatens-key-theory-alzheimers-disease https://www.science.org/content/article/potential-fabricatio...
cc101 4y ago
I'm 76. Have declining cognitive function. Have been taking D3 for over a decade. Damn! I don't know what to do other than to experiment with not taking D3.
- himinlomax 4y ago
  Are you a mouse? In that case, you should indeed be worried. If not, just carry on doing what you've been doing.
- robwwilliams 4y ago
  Try 2-3 gm of niacinamide (non-flushing Vit B3). This vitamin keeps mitochondria happy. Start slowly (1 gm/day) and after a month or two ramp up if all is good to 3 gm/day.
  - eurasiantiger 4y ago
    It is interesting that the amide form of nicotine is so essential for humans. ”In 1942, when flour enrichment with nicotinic acid began, a headline in the popular press said "Tobacco in Your Bread." In response, the Council on Foods and Nutrition of the American Medical Association approved of the Food and Nutrition Board's new names niacin and niacin amide for use primarily by non-scientists. It was thought appropriate to choose a name to dissociate nicotinic acid from nicotine, to avoid the perception that vitamins or niacin-rich food contains nicotine, or that cigarettes contain vitamins. The resulting name niacin was derived from nicotinic acid + vitamin.”
- flowcont 4y ago
  In a reddit thread I read about the link between the gut biome and different diseases. Someone commented about custom probiotics and that they had seen improvements. They were in the US and they had used flore (I have no idea about them). I think it's worth a try.
- pawsforthought 4y ago
  Get some sun [1]. Might not help, but I bet you’ll enjoy it all the same. [1]: https://www.outsideonline.com/health/wellness/sunscreen-sun-exposure-skin-cancer-science/ https://www.outsideonline.com/health/wellness/sunscreen-sun-...
- JPLeRouzic 4y ago
  I am 65. 20 years ago I am pretty sure I had declining cognitive functions. At the time I was a good research engineer, but actually I was morbidly obese, was unable to walk 2km (~1.2 miles). Yet now I think I am better. What changed? I retired, move to an home in a nice rural setting and tried to improve my health through exercise and loosing weight. I was not easy but I am now able to walk 20km (13 miles) (I even did a 33km round trip). I didn't regain ability to run more than one hundred yards though. Another thing is try to improve your cardiovascular health, a stroke is something devastating. Good luck!
TrinaryWorksToo 4y ago
Or it might improve the condition: https://pubmed.ncbi.nlm.nih.gov/29447107/ https://pubmed.ncbi.nlm.nih.gov/29447107/ Vitamin D status and risk of dementia and Alzheimer's disease: A meta-analysis of dose-response Science is hard, and effect sizes matter.

39 points by nojs 4y ago

New territory. Needs really deep research.

In Alzheimer mice models, which are completely flawed to begin with. Another pure junk headline. They also did a retrospective population-based cohort study (no intervention), which is not enough to prove any kind of causality and is prone to confounding factors that can't be easily controlled for (how much time people spend in the sun every day will have a huge impact in their Vitamin D levels and their needs for supplementation or not).

robwwilliams 4y ago
You may well be right. But there are good and bad mouse models of early onset Alzheimer’s. The best is the AD-BXD mouse family model of C. Kaczorowski and colleagues. This “model” is genetically diverse—like humans.

scrollaway 4y ago

I can't possibly believe any Alzheimer's research right now. https://www.dailykos.com/stories/2022/7/22/2111914/-Two-decades-of-Alzheimer-s-research-may-be-based-on-deliberate-fraud-that-has-cost-millions-of-lives https://www.dailykos.com/stories/2022/7/22/2111914/-Two-deca... https://www.science.org/content/article/potential-fabrication-research-images-threatens-key-theory-alzheimers-disease https://www.science.org/content/article/potential-fabricatio...

cc101 4y ago

I'm 76. Have declining cognitive function. Have been taking D3 for over a decade. Damn! I don't know what to do other than to experiment with not taking D3.

himinlomax 4y ago
Are you a mouse? In that case, you should indeed be worried. If not, just carry on doing what you've been doing.
robwwilliams 4y ago
Try 2-3 gm of niacinamide (non-flushing Vit B3). This vitamin keeps mitochondria happy. Start slowly (1 gm/day) and after a month or two ramp up if all is good to 3 gm/day.
- eurasiantiger 4y ago
  It is interesting that the amide form of nicotine is so essential for humans. ”In 1942, when flour enrichment with nicotinic acid began, a headline in the popular press said "Tobacco in Your Bread." In response, the Council on Foods and Nutrition of the American Medical Association approved of the Food and Nutrition Board's new names niacin and niacin amide for use primarily by non-scientists. It was thought appropriate to choose a name to dissociate nicotinic acid from nicotine, to avoid the perception that vitamins or niacin-rich food contains nicotine, or that cigarettes contain vitamins. The resulting name niacin was derived from nicotinic acid + vitamin.”
flowcont 4y ago
In a reddit thread I read about the link between the gut biome and different diseases. Someone commented about custom probiotics and that they had seen improvements. They were in the US and they had used flore (I have no idea about them). I think it's worth a try.
pawsforthought 4y ago
Get some sun [1]. Might not help, but I bet you’ll enjoy it all the same. [1]: https://www.outsideonline.com/health/wellness/sunscreen-sun-exposure-skin-cancer-science/ https://www.outsideonline.com/health/wellness/sunscreen-sun-...
JPLeRouzic 4y ago
I am 65. 20 years ago I am pretty sure I had declining cognitive functions. At the time I was a good research engineer, but actually I was morbidly obese, was unable to walk 2km (~1.2 miles). Yet now I think I am better. What changed? I retired, move to an home in a nice rural setting and tried to improve my health through exercise and loosing weight. I was not easy but I am now able to walk 20km (13 miles) (I even did a 33km round trip). I didn't regain ability to run more than one hundred yards though. Another thing is try to improve your cardiovascular health, a stroke is something devastating. Good luck!

TrinaryWorksToo 4y ago

Or it might improve the condition: https://pubmed.ncbi.nlm.nih.gov/29447107/ https://pubmed.ncbi.nlm.nih.gov/29447107/ Vitamin D status and risk of dementia and Alzheimer's disease: A meta-analysis of dose-response Science is hard, and effect sizes matter.