3 ms·

Previous released papers have found that the earlier Omicron variants did not provide protection from middle variants. (Original omicron vs BA1/2). So some bA.2

by dv_dt 4y ago

Previous released papers have found that the earlier Omicron variants did not provide protection from middle variants. (Original omicron vs BA1/2). So some bA.2 to BA4/5 immunity protection would be a new behavior. https://www.science.org/doi/10.1126/science.abq1841 https://www.science.org/doi/10.1126/science.abq1841

peteradio 4y ago
Serology studies don't tell you health outcomes.
- dv_dt 4y ago
  How is immune protection measured? It would seem like you can't skip serology measurements - otherwise how would one know if the participants even had an immune response to the variants you were studying? But it does make sense to further associate outcomes with the serology. But that doesn't have to happen in the same studies and coudl be covered by separate studies.
  - peteradio 4y ago
    Immunity doesn't only come from antibodies, but frustratingly we get misleading headlines like "prior infection from omicron does not boost immunity" or the like and when you look at where those statements are coming from you discover its based entirely on blood tests which only cover a narrow window of the immunity picture. Its like putting a hand over one eye and claiming you can't see.
jancsika 4y ago
Of course some variants were found not to protect against reinfection. The inability to predict protection against future variants is stuff you'd learn in any first course in infectious diseases. People keep treating rocket science like it's epidemiology, but it really isn't.
colechristensen 4y ago
You are generalizing too much. “Did not provide protection” is not an adequate summary of your source.
nodamage 4y ago
That's not actually what this paper says. Reduced neutralization in a lab experiment doesn't necessarily imply zero protection in the real world. (As we're now finding out.)

3 ms·

Previous released papers have found that the earlier Omicron variants did not provide protection from middle variants. (Original omicron vs BA1/2). So some bA.2

by dv_dt 4y ago

peteradio 4y ago
Serology studies don't tell you health outcomes.
- dv_dt 4y ago
  How is immune protection measured? It would seem like you can't skip serology measurements - otherwise how would one know if the participants even had an immune response to the variants you were studying? But it does make sense to further associate outcomes with the serology. But that doesn't have to happen in the same studies and coudl be covered by separate studies.
  - peteradio 4y ago
    Immunity doesn't only come from antibodies, but frustratingly we get misleading headlines like "prior infection from omicron does not boost immunity" or the like and when you look at where those statements are coming from you discover its based entirely on blood tests which only cover a narrow window of the immunity picture. Its like putting a hand over one eye and claiming you can't see.
jancsika 4y ago
Of course some variants were found not to protect against reinfection. The inability to predict protection against future variants is stuff you'd learn in any first course in infectious diseases. People keep treating rocket science like it's epidemiology, but it really isn't.
colechristensen 4y ago
You are generalizing too much. “Did not provide protection” is not an adequate summary of your source.
nodamage 4y ago
That's not actually what this paper says. Reduced neutralization in a lab experiment doesn't necessarily imply zero protection in the real world. (As we're now finding out.)