4 ms·

I recommend reading these instead: Alzheimer’s amyloid hypothesis ‘cabal’ thwarted progress toward a cure (2019) https://news.ycombinator.com/item?id=31828509

I recommend reading these instead: Alzheimer’s amyloid hypothesis ‘cabal’ thwarted progress toward a cure (2019) https://news.ycombinator.com/item?id=31828509 https://news.ycombinator.com/item?id=31828509 How an Alzheimer’s ‘cabal’ thwarted progress toward a cure https://news.ycombinator.com/item?id=21911225 https://news.ycombinator.com/item?id=21911225 The amyloid hypothesis on trial https://news.ycombinator.com/item?id=17618027 https://news.ycombinator.com/item?id=17618027 Is the Alzheimer's “Amyloid Hypothesis” Wrong? (2017) https://news.ycombinator.com/item?id=17444214 https://news.ycombinator.com/item?id=17444214 Why, at this point should we believe any one scientist writing in that forum wasn't already sunk far deep into amyloid research in their career? Not to mention that after a quick glance on the comments section, I fail to see where you get the idea that "They all disagree with the notion that Lesné's papers have been important to the field". Apart from the very first comment from karen Ashe (who will obviously be defending her research) and a few other who's working on related topics, other commenters seems to be keeping their suspicion at amyloid hypothesis.

user1337331 4y ago
Rather than just scrutinizing a single hypothesis for AD we must understand that it is a multi factorial disease and that there are other hypotheses as well (i.e., acetylcholine, tau, transport-clearance), which affect and complicate this disease. Furthermore, we know very little about the brain, hence why novel therapies consistently fail in the clinic compared to other diseases (i.e., cancer). Most of these antibodies that target amyloid don’t even cross the blood-brain barrier (<0.1% and need an effective dose of 1000x blood-plasma for effective amyloid lowering) - provided with this, can we really attest the failure of the amyloid hypothesis? Moreover, the commenters there are big names in the AD community

user1337331 4y ago

Rather than just scrutinizing a single hypothesis for AD we must understand that it is a multi factorial disease and that there are other hypotheses as well (i.e., acetylcholine, tau, transport-clearance), which affect and complicate this disease. Furthermore, we know very little about the brain, hence why novel therapies consistently fail in the clinic compared to other diseases (i.e., cancer). Most of these antibodies that target amyloid don’t even cross the blood-brain barrier (<0.1% and need an effective dose of 1000x blood-plasma for effective amyloid lowering) - provided with this, can we really attest the failure of the amyloid hypothesis? Moreover, the commenters there are big names in the AD community