I think you hit it exactly right. There are so many ways that are studies can be flawed either accidentally or purposefully. I truly assume most studies are n

I think you hit it exactly right. There are so many ways that are studies can be flawed either accidentally or purposefully. I truly assume most studies are not purposefully fraudulent - people, by and large, are honest... but I do believe there are enough problems with our current methods that most studies are not truly accurate. Having a publish clinical trial regimen - created before your study starts - helps with a lot of this. It answers how you segment patients, match patients, handle patient dropout, and specifies what you are trying to compare for outcomes. Is it the end-all be-all? obviously not. I don't know what the true answer is.