Personally, I think the depression is just a side effect of dealing with how society moulds you to work in an office. I have worked full time in an office twice

Personally, I think the depression is just a side effect of dealing with how society moulds you to work in an office. I have worked full time in an office twice, and I went through depression (unofficially, as I don't want anything to do with those drugs) for several months after leaving. Offices desensitize employees to lots of distractions, which seem to become addictive: phones ringing non-stop, colleagues interrupting, clients visiting, random music playing in the background, fitting in with certain rules etc. The silence of working from home is refreshing at first, but then the dark clouds kick in and you start to adapt. Exercise is the best cure to depression.