Yes, the Asian flush gene comes with a headache and nausea for some. Two friends who experience versions of this had it confirmed on their 23andme results. Expl

Yes, the Asian flush gene comes with a headache and nausea for some. Two friends who experience versions of this had it confirmed on their 23andme results. Explanation: > Alcohol or ethanol is broken down or converted in the liver to acetaldehyde, a highly toxic compound that contributes to the hungover feeling. In most people, acetaldehyde is rapidly transformed to harmless acetate and water. > However, for some Asians, Ashkenazi Jews and others whose gene pool contains a mutant or altered form of the ALDH2 gene, the toxic acetaldehyde isn’t broken down as quickly, so it hangs around and accumulates in the liver and body [...] https://news.usc.edu/112489/antihistamines-prevent-asian-flush-the-red-face-some-people-get-from-alcohol-but-with-huge-risks https://news.usc.edu/112489/antihistamines-prevent-asian-flu... The thing I really wonder is whether on balance, this works out to be a bug or a feature. Personally I don't get a headache, but I also don't feel the euphoria that many clearly do.