Gain-of-function research, conducted carefully enough, might expose risks ahead of time that could be vaccinated against. You would generally prefer that it be

Gain-of-function research, conducted carefully enough, might expose risks ahead of time that could be vaccinated against. You would generally prefer that it be in pathogens not already adapted to humans, or in places those are handled. We are guaranteed pandemics regardless, just by how much international travel we do. What matters is the response. We are lucky monkeypox (actually a rodent illness) is rarely fatal.