How our brains respond to circumstances is essentially chemical. Perhaps some peoples brains don't do well without a particular cultural or social context and w

How our brains respond to circumstances is essentially chemical. Perhaps some peoples brains don't do well without a particular cultural or social context and we ultimately see that at the physical level with the chemical changes that result from it. Maybe the brain is really saying "change the circumstances" and we're interpreting it as "chemical proportions are off and/or chemical receptors are responding differently" and seek to correct the physical component. I know there are people who are chronically depressed but I don't know how to untangle them from the context in which their disease exists. The only way to really know would be to try adapting them to wholly different circumstances and see whether or not the way the brain responded changed as a result.