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Paracetamol and Ibuprofen is a magic mix - and it's safe to throw Codeine on top as well if the pain warrants it. From personal experience I've never been wowe

Paracetamol and Ibuprofen is a magic mix - and it's safe to throw Codeine on top as well if the pain warrants it. From personal experience I've never been wowed by Paracetamol in tablet form, however after experiencing it in liquid form via IV - wow; it's a surprisingly capable analgesic. I'd also point out that whilst Ibuprofen and other NAISDs can be great for short term inflammation, it can lead to worst long-term healing/outcomes. Depending on how you've damaged yourself (I shattered both my heels) it might actually be more beneficial long term _not_ to use it. Worth researching if you manage to do something serious (though I'd suggest avoiding the damage in the first place). edit: spelling

samtho 4y ago
> From personal experience I've never been wowed by Paracetamol in tablet form, however after experiencing it in liquid form via IV - wow; it's a surprisingly capable analgesic. Part of this is because the oral route is very damaging to some types of substances, I.e. molocules are getting digested before they even reach the liver - where paracetamol/acetaminophen is metabolized and becomes bioavailable. If I recall correctly, the maximum dosage on the bottle is typically the maximum under the assumption that all of the medicine hits the liver. Because everyone’s gut biomes and digestive enzymes are slightly different, everyone has a different amount that actually reaches the liver. Taking it IV skips the harsh environment of the stomach and doctors can give you the maximum safe dose which ends up being way more than you can get via the oral route at the same level. > I’d also point out that whilst Ibuprofen and other NAISDs can be great for short term inflammation, it can lead to worst long-term healing/outcomes I wish this was more studied because, while this is true, there is way more nuance that they’ve been able to capture. My partner is allergic to paracetamol/acetaminophen and stronger pain relievers get compounded with that so she has to get it compounded with ibuprofen. After a surgery she had however, there were few options because her surgeon did not want her to take any kind of blood thinners. Luckily, she is sensitive to the numbing effects of ibuprofen so she takes a low dose (200-400mg vs 800-1200mg) and he gave her the clear to have up to 400mg every 6 hours. There is also the danger of ulcers developing because it affects the stomach pH drastically, but can be mitigated with large quantities of water or food to help buffer it.

samtho 4y ago

> From personal experience I've never been wowed by Paracetamol in tablet form, however after experiencing it in liquid form via IV - wow; it's a surprisingly capable analgesic. Part of this is because the oral route is very damaging to some types of substances, I.e. molocules are getting digested before they even reach the liver - where paracetamol/acetaminophen is metabolized and becomes bioavailable. If I recall correctly, the maximum dosage on the bottle is typically the maximum under the assumption that all of the medicine hits the liver. Because everyone’s gut biomes and digestive enzymes are slightly different, everyone has a different amount that actually reaches the liver. Taking it IV skips the harsh environment of the stomach and doctors can give you the maximum safe dose which ends up being way more than you can get via the oral route at the same level. > I’d also point out that whilst Ibuprofen and other NAISDs can be great for short term inflammation, it can lead to worst long-term healing/outcomes I wish this was more studied because, while this is true, there is way more nuance that they’ve been able to capture. My partner is allergic to paracetamol/acetaminophen and stronger pain relievers get compounded with that so she has to get it compounded with ibuprofen. After a surgery she had however, there were few options because her surgeon did not want her to take any kind of blood thinners. Luckily, she is sensitive to the numbing effects of ibuprofen so she takes a low dose (200-400mg vs 800-1200mg) and he gave her the clear to have up to 400mg every 6 hours. There is also the danger of ulcers developing because it affects the stomach pH drastically, but can be mitigated with large quantities of water or food to help buffer it.