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Combined paracetamol and ibuprofen is king Ive found and they both work well together and dont seem dangerous. If you follow the dosage. Combine with Caffeine t

Combined paracetamol and ibuprofen is king Ive found and they both work well together and dont seem dangerous. If you follow the dosage. Combine with Caffeine too. >It's safe to take ibuprofen with paracetamol or codeine. https://www.nhs.uk/medicines/ibuprofen-for-adults/taking-ibuprofen-with-other-medicines-and-herbal-supplements/ https://www.nhs.uk/medicines/ibuprofen-for-adults/taking-ibu...

MisterBastahrd 4y ago
For those who don't know, paracetamol is also known as acetaminophen. Goody's is my go-to for headaches and minor aches and pains. It's sold in powder packs here in the US with some optional flavoring added and contains acetaminophen, aspirin, and caffeine.
- xxpor 4y ago
  I believe that's what Excedrin is as well (as a tablet of course)
- oynqr 4y ago
  Paracetamol is also a leader in deadly prescription drug overdoses.
  - rejectfinite 4y ago
    This is because of Percocet and Tramadol that combine opiates and paracetamol. Paracetamol is easy to overdose on because the opiate is lower in those. paracetamol is perscription free.
    - Galaxity 4y ago
      Tramadol is the opiate itself, it does not have paracetamol. There are other brand pills that contain both. Paracetamol does not contain an opiate. It is a different substance from opiates. It is, however, dangerous to the liver in large amounts.
  - Mikeb85 4y ago
    Because it affects the liver thus large quantities are dangerous and having it with alcohol is dangerous. This is why ibuprofen is so miraculous; you can take it with alcohol lol.
  - pessimizer 4y ago
    > Paracetamol poisoning is the foremost cause of acute liver failure in the Western world, and accounts for most drug overdoses in the United States, the United Kingdom, Australia, and New Zealand. https://en.wikipedia.org/wiki/Paracetamol https://en.wikipedia.org/wiki/Paracetamol > Analysis of national mortality files shows about 450 deaths occur each year from acetaminophen-associated overdoses; 100 of these are unintentional. https://www.acsh.org/news/2017/09/11/tylenol-far-most-dangerous-drug-ever-made-11711 https://www.acsh.org/news/2017/09/11/tylenol-far-most-danger... edit: https://www.propublica.org/article/tylenol-mcneil-fda-use-only-as-directed https://www.propublica.org/article/tylenol-mcneil-fda-use-on...
opan 4y ago
Almost sounds like a knockoff ECA stack.
BuildTheRobots 4y ago
Paracetamol and Ibuprofen is a magic mix - and it's safe to throw Codeine on top as well. From personal experience I've never been wowed by Paracetamol in tablet form, however after experiencing it in liquid form via IV - wow; it's a surprisingly capable analgesic. I'd also point out that whilst Ibuprofen and other NAISDs can be great for short term inflammation, it can lead to worst long-term healing/outcomes. Depending on how you've damaged yourself (I shattered both my heels) it might actually be more beneficial long term _not_ to use it.
worker_person 4y ago
Fun fact, if you're having a lot of headaches and take pain killers daily you can start suffering rebound headaches. Basically a highly painful headache caused by the pain killers. This creates a nasty feedback loop. If your suffering head pain try and rotate pain killers and have days of no pain killers. Of course you should be trying to find out the reasons for the pain so you can stop taking them.
- rejectfinite 4y ago
  I never would take painkillers daily unless prescribed! That is dangerous and I know it. Why would you think/do this?
  - BoorishBears 4y ago
    > Combined paracetamol and ibuprofen is king Ive found and they both work well together and dont seem dangerous. If you follow the dosage. Combine with Caffeine too. The way this was worded didn't make it unreasonable to assume you often take painkillers...
    - rejectfinite 4y ago
      Well, I don't think so and I don't? _So...
      - BoorishBears 4y ago
        It's fine that you don't think so, but that's how it was worded. "Casual" painkiller users tend to take what's on hand and aren't trying to build three medication stacks with caffeine.
        rejectfinite 4y ago
        When I am in pain I want it to go away. This is what I found works best over the years. Last time I used it getting Covid vaccine after effects fever. So awhile ago.
BuildTheRobots 4y ago
Paracetamol and Ibuprofen is a magic mix - and it's safe to throw Codeine on top as well if the pain warrants it. From personal experience I've never been wowed by Paracetamol in tablet form, however after experiencing it in liquid form via IV - wow; it's a surprisingly capable analgesic. I'd also point out that whilst Ibuprofen and other NAISDs can be great for short term inflammation, it can lead to worst long-term healing/outcomes. Depending on how you've damaged yourself (I shattered both my heels) it might actually be more beneficial long term _not_ to use it. Worth researching if you manage to do something serious (though I'd suggest avoiding the damage in the first place). edit: spelling
- samtho 4y ago
  > From personal experience I've never been wowed by Paracetamol in tablet form, however after experiencing it in liquid form via IV - wow; it's a surprisingly capable analgesic. Part of this is because the oral route is very damaging to some types of substances, I.e. molocules are getting digested before they even reach the liver - where paracetamol/acetaminophen is metabolized and becomes bioavailable. If I recall correctly, the maximum dosage on the bottle is typically the maximum under the assumption that all of the medicine hits the liver. Because everyone’s gut biomes and digestive enzymes are slightly different, everyone has a different amount that actually reaches the liver. Taking it IV skips the harsh environment of the stomach and doctors can give you the maximum safe dose which ends up being way more than you can get via the oral route at the same level. > I’d also point out that whilst Ibuprofen and other NAISDs can be great for short term inflammation, it can lead to worst long-term healing/outcomes I wish this was more studied because, while this is true, there is way more nuance that they’ve been able to capture. My partner is allergic to paracetamol/acetaminophen and stronger pain relievers get compounded with that so she has to get it compounded with ibuprofen. After a surgery she had however, there were few options because her surgeon did not want her to take any kind of blood thinners. Luckily, she is sensitive to the numbing effects of ibuprofen so she takes a low dose (200-400mg vs 800-1200mg) and he gave her the clear to have up to 400mg every 6 hours. There is also the danger of ulcers developing because it affects the stomach pH drastically, but can be mitigated with large quantities of water or food to help buffer it.
wwalexander 4y ago
I get migraines (not as frequently as when I was young, but still quite often) and caffeine is key—my pediatrician told my mom to get me a Coke if I was coming on with a migraine, which I was of course thrilled about as a kid. I also find that combined ibuprofen and acetaminophen has the best results, though if I had to choose one for a desert island I’d take Advil Liqui-Gels since they don’t hurt my stomach if I haven’t eaten/am unable to eat.
- nick_ 4y ago
  Yep, that's the NSAID-acetaminophen-caffeine trifecta that Excedrin uses (and it's generic counterparts, of course).
Mikeb85 4y ago
Last time I had COVID the doctor literally recommended ibuprofen+ paracetamol and caffeine together lol. Not gonna lie, definitely a good cocktail.

MisterBastahrd 4y ago

For those who don't know, paracetamol is also known as acetaminophen. Goody's is my go-to for headaches and minor aches and pains. It's sold in powder packs here in the US with some optional flavoring added and contains acetaminophen, aspirin, and caffeine.

xxpor 4y ago
I believe that's what Excedrin is as well (as a tablet of course)
oynqr 4y ago
Paracetamol is also a leader in deadly prescription drug overdoses.
- rejectfinite 4y ago
  This is because of Percocet and Tramadol that combine opiates and paracetamol. Paracetamol is easy to overdose on because the opiate is lower in those. paracetamol is perscription free.
  - Galaxity 4y ago
    Tramadol is the opiate itself, it does not have paracetamol. There are other brand pills that contain both. Paracetamol does not contain an opiate. It is a different substance from opiates. It is, however, dangerous to the liver in large amounts.
- Mikeb85 4y ago
  Because it affects the liver thus large quantities are dangerous and having it with alcohol is dangerous. This is why ibuprofen is so miraculous; you can take it with alcohol lol.
- pessimizer 4y ago
  > Paracetamol poisoning is the foremost cause of acute liver failure in the Western world, and accounts for most drug overdoses in the United States, the United Kingdom, Australia, and New Zealand. https://en.wikipedia.org/wiki/Paracetamol https://en.wikipedia.org/wiki/Paracetamol > Analysis of national mortality files shows about 450 deaths occur each year from acetaminophen-associated overdoses; 100 of these are unintentional. https://www.acsh.org/news/2017/09/11/tylenol-far-most-dangerous-drug-ever-made-11711 https://www.acsh.org/news/2017/09/11/tylenol-far-most-danger... edit: https://www.propublica.org/article/tylenol-mcneil-fda-use-only-as-directed https://www.propublica.org/article/tylenol-mcneil-fda-use-on...

opan 4y ago

Almost sounds like a knockoff ECA stack.

BuildTheRobots 4y ago

Paracetamol and Ibuprofen is a magic mix - and it's safe to throw Codeine on top as well. From personal experience I've never been wowed by Paracetamol in tablet form, however after experiencing it in liquid form via IV - wow; it's a surprisingly capable analgesic. I'd also point out that whilst Ibuprofen and other NAISDs can be great for short term inflammation, it can lead to worst long-term healing/outcomes. Depending on how you've damaged yourself (I shattered both my heels) it might actually be more beneficial long term _not_ to use it.

worker_person 4y ago

Fun fact, if you're having a lot of headaches and take pain killers daily you can start suffering rebound headaches. Basically a highly painful headache caused by the pain killers. This creates a nasty feedback loop. If your suffering head pain try and rotate pain killers and have days of no pain killers. Of course you should be trying to find out the reasons for the pain so you can stop taking them.

rejectfinite 4y ago
I never would take painkillers daily unless prescribed! That is dangerous and I know it. Why would you think/do this?
- BoorishBears 4y ago
  > Combined paracetamol and ibuprofen is king Ive found and they both work well together and dont seem dangerous. If you follow the dosage. Combine with Caffeine too. The way this was worded didn't make it unreasonable to assume you often take painkillers...
  - rejectfinite 4y ago
    Well, I don't think so and I don't? _So...
    - BoorishBears 4y ago
      It's fine that you don't think so, but that's how it was worded. "Casual" painkiller users tend to take what's on hand and aren't trying to build three medication stacks with caffeine.
      - rejectfinite 4y ago
        When I am in pain I want it to go away. This is what I found works best over the years. Last time I used it getting Covid vaccine after effects fever. So awhile ago.

BuildTheRobots 4y ago

Paracetamol and Ibuprofen is a magic mix - and it's safe to throw Codeine on top as well if the pain warrants it. From personal experience I've never been wowed by Paracetamol in tablet form, however after experiencing it in liquid form via IV - wow; it's a surprisingly capable analgesic. I'd also point out that whilst Ibuprofen and other NAISDs can be great for short term inflammation, it can lead to worst long-term healing/outcomes. Depending on how you've damaged yourself (I shattered both my heels) it might actually be more beneficial long term _not_ to use it. Worth researching if you manage to do something serious (though I'd suggest avoiding the damage in the first place). edit: spelling

samtho 4y ago
> From personal experience I've never been wowed by Paracetamol in tablet form, however after experiencing it in liquid form via IV - wow; it's a surprisingly capable analgesic. Part of this is because the oral route is very damaging to some types of substances, I.e. molocules are getting digested before they even reach the liver - where paracetamol/acetaminophen is metabolized and becomes bioavailable. If I recall correctly, the maximum dosage on the bottle is typically the maximum under the assumption that all of the medicine hits the liver. Because everyone’s gut biomes and digestive enzymes are slightly different, everyone has a different amount that actually reaches the liver. Taking it IV skips the harsh environment of the stomach and doctors can give you the maximum safe dose which ends up being way more than you can get via the oral route at the same level. > I’d also point out that whilst Ibuprofen and other NAISDs can be great for short term inflammation, it can lead to worst long-term healing/outcomes I wish this was more studied because, while this is true, there is way more nuance that they’ve been able to capture. My partner is allergic to paracetamol/acetaminophen and stronger pain relievers get compounded with that so she has to get it compounded with ibuprofen. After a surgery she had however, there were few options because her surgeon did not want her to take any kind of blood thinners. Luckily, she is sensitive to the numbing effects of ibuprofen so she takes a low dose (200-400mg vs 800-1200mg) and he gave her the clear to have up to 400mg every 6 hours. There is also the danger of ulcers developing because it affects the stomach pH drastically, but can be mitigated with large quantities of water or food to help buffer it.

wwalexander 4y ago

I get migraines (not as frequently as when I was young, but still quite often) and caffeine is key—my pediatrician told my mom to get me a Coke if I was coming on with a migraine, which I was of course thrilled about as a kid. I also find that combined ibuprofen and acetaminophen has the best results, though if I had to choose one for a desert island I’d take Advil Liqui-Gels since they don’t hurt my stomach if I haven’t eaten/am unable to eat.

nick_ 4y ago
Yep, that's the NSAID-acetaminophen-caffeine trifecta that Excedrin uses (and it's generic counterparts, of course).

Mikeb85 4y ago

Last time I had COVID the doctor literally recommended ibuprofen+ paracetamol and caffeine together lol. Not gonna lie, definitely a good cocktail.