Has any study ever been able to induce depression reliably by reducing neurotransmitters? As someone who once had depression that did not respond to any medica

Has any study ever been able to induce depression reliably by reducing neurotransmitters? As someone who once had depression that did not respond to any medication, which was completely resolved within 1-2 weeks of making a big but well planned life change, in retrospect I consider what was done to me borderline malpractice, considering some of the sude effects.