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Since this is HN, does anyone know of new advances in cartilage repair? I just a deep cartilage defect in my femur at the knee joint because one stupid squash g

by fruit2020 4y ago

Since this is HN, does anyone know of new advances in cartilage repair? I just a deep cartilage defect in my femur at the knee joint because one stupid squash game. Reading about osteoarthritis is so depressing. Take care of your knees!

deleted 4y ago
[deleted]
t_mann 4y ago
Nutrition and regular movement. Don't worry, you'll be fine, had a similar thing a few years ago, all gone. Be careful about surgeries, last time I checked the consensus seemed to be converging on that in this case they're largely placebos.
doix 4y ago
Depending on how far off the deep-end you want to go, you can look into: peptides (BPC-157, TB-500), Human Growth Hormone and Platelet-Rich Plasma injections (PRP). There might be more stuff out there now, it's been a few years since I looked into it for a SLAP tear in my shoulder. If you are in the USA, look into "anti aging" or "longevity" clinics. It's basically gymbro MD's that will prescribe you that stuff for money. Then at least you can be fairly certain that you know what you're injecting. Otherwise, you're at the mercy of the dodgy websites/alibaba for acquiring the stuff. Obviously there is no definitive proof that the stuff works or if it's safe, otherwise it would be significantly more common. You can google, there are many small scale studies done on those compounds of varying degrees of quality. It all depends on your risk-tolerances etc. Ideally you'd be somewhere in the US near one of those clinics and could speak to a real doctor about your options, and not a random idiot from hackernews :D.
- gavinray 4y ago
  BPC-157 is your best shot, have loads of experience with it and nothing but good things to say. Have also used TB-500, and a dozen other peptides, but for injuries there's nothing like BPC. Unfortunately the feds are starting to crack down both SARMs and Peptides so they aren't as easy to get as they were 5 years ago =/
azalemeth 4y ago
There are two mainstream competing methods – microfracturing and autologous transplantation of osteochondral stem cells ("autologous" meaning "from you" as opposed to "from someone else"l this procedure is sometimes called OAT – osteochondral autologous transplantation) – that can be applied if you have a focal defect. There is good evidence that both are better than doing nothing. By "good evidence" I mean "a meta-analysis of peer-reviewed randomised clinical trials" – see [1] for microfracturing and [2, 3] for OAT. I would argue that there is no clear winner. I had a bucket-handle tear of my right lateral meniscus, chondromalacia patellae grade 3 and a patellar tendinopathy. I was operated on for these about a year ago and am only really just able to walk again. I also have at least two herniated and seven prolapsed spinal discs with cord moulding and neuropathy and neurological symptoms. Videos like this make me feel a bit sick, to be honest. [1] https://link.springer.com/article/10.1007/s00264-011-1364-x https://link.springer.com/article/10.1007/s00264-011-1364-x [2] https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0040-1716552?casa_token=4Uy7VOEkwL8AAAAA:f-BmFnPWjvBEaZJX2RExilGX_tWWGG9GIyeJblyid-oX1FAUs8Me9Bug55Ai35yiCik0y6bY3BriQgE https://www.thieme-connect.com/products/ejournals/html/10.10... [3] https://doi.org/10.1016/j.arthro.2016.05.038 https://doi.org/10.1016/j.arthro.2016.05.038
darkerside 4y ago
Similar situation here. Trying to go without surgery. Doctors said my partial ACL tear wouldn't heal. They were wrong. But it took a lot of rehab and learning new movement patterns. They're saying the same thing now. I'm hoping it's another case of, statistically these things don't heal because people don't change their movement patterns, not because it's impossible. Besides a light brace, stretching and massage, I am taking collagen supplements. Considering PRP. Good luck with your journey!
- ExciteByte 4y ago
  It seems like most doctors and your average physical therapist, lack the knowledge on what can be achived with a conservative approach. Just google what knee injury Connor McDavid (Arguably the best and most dynamic player in the NHL) had, and the sucessful non-surgical rehab protocal he went through. Most of his doctors were pressuring him to go the surgical route.

deleted 4y ago

[deleted]

t_mann 4y ago

Nutrition and regular movement. Don't worry, you'll be fine, had a similar thing a few years ago, all gone. Be careful about surgeries, last time I checked the consensus seemed to be converging on that in this case they're largely placebos.

doix 4y ago

Depending on how far off the deep-end you want to go, you can look into: peptides (BPC-157, TB-500), Human Growth Hormone and Platelet-Rich Plasma injections (PRP). There might be more stuff out there now, it's been a few years since I looked into it for a SLAP tear in my shoulder. If you are in the USA, look into "anti aging" or "longevity" clinics. It's basically gymbro MD's that will prescribe you that stuff for money. Then at least you can be fairly certain that you know what you're injecting. Otherwise, you're at the mercy of the dodgy websites/alibaba for acquiring the stuff. Obviously there is no definitive proof that the stuff works or if it's safe, otherwise it would be significantly more common. You can google, there are many small scale studies done on those compounds of varying degrees of quality. It all depends on your risk-tolerances etc. Ideally you'd be somewhere in the US near one of those clinics and could speak to a real doctor about your options, and not a random idiot from hackernews :D.

gavinray 4y ago
BPC-157 is your best shot, have loads of experience with it and nothing but good things to say. Have also used TB-500, and a dozen other peptides, but for injuries there's nothing like BPC. Unfortunately the feds are starting to crack down both SARMs and Peptides so they aren't as easy to get as they were 5 years ago =/

azalemeth 4y ago

There are two mainstream competing methods – microfracturing and autologous transplantation of osteochondral stem cells ("autologous" meaning "from you" as opposed to "from someone else"l this procedure is sometimes called OAT – osteochondral autologous transplantation) – that can be applied if you have a focal defect. There is good evidence that both are better than doing nothing. By "good evidence" I mean "a meta-analysis of peer-reviewed randomised clinical trials" – see [1] for microfracturing and [2, 3] for OAT. I would argue that there is no clear winner. I had a bucket-handle tear of my right lateral meniscus, chondromalacia patellae grade 3 and a patellar tendinopathy. I was operated on for these about a year ago and am only really just able to walk again. I also have at least two herniated and seven prolapsed spinal discs with cord moulding and neuropathy and neurological symptoms. Videos like this make me feel a bit sick, to be honest. [1] https://link.springer.com/article/10.1007/s00264-011-1364-x https://link.springer.com/article/10.1007/s00264-011-1364-x [2] https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0040-1716552?casa_token=4Uy7VOEkwL8AAAAA:f-BmFnPWjvBEaZJX2RExilGX_tWWGG9GIyeJblyid-oX1FAUs8Me9Bug55Ai35yiCik0y6bY3BriQgE https://www.thieme-connect.com/products/ejournals/html/10.10... [3] https://doi.org/10.1016/j.arthro.2016.05.038 https://doi.org/10.1016/j.arthro.2016.05.038

darkerside 4y ago

Similar situation here. Trying to go without surgery. Doctors said my partial ACL tear wouldn't heal. They were wrong. But it took a lot of rehab and learning new movement patterns. They're saying the same thing now. I'm hoping it's another case of, statistically these things don't heal because people don't change their movement patterns, not because it's impossible. Besides a light brace, stretching and massage, I am taking collagen supplements. Considering PRP. Good luck with your journey!

ExciteByte 4y ago
It seems like most doctors and your average physical therapist, lack the knowledge on what can be achived with a conservative approach. Just google what knee injury Connor McDavid (Arguably the best and most dynamic player in the NHL) had, and the sucessful non-surgical rehab protocal he went through. Most of his doctors were pressuring him to go the surgical route.