Have you ever tried 5-HT2A antagonists or inverse agonists like trazodone, mirtazapine, or the dozens of atypical antipsychotics that are indicated for depressi

Have you ever tried 5-HT2A antagonists or inverse agonists like trazodone, mirtazapine, or the dozens of atypical antipsychotics that are indicated for depression? I ask because I wonder if the rapid tolerance at 5-HT2A is responsible for the therapeutic response you get from psychedelics, and if antagonists or inverse agonists can emulate that tolerance in a sustainable way that doesn't require regular psychedelic experiences. Those experiences can be great, but the potential for bad experiences might be a Faustian bargain.