I worked in a lab doing research based on that amyloid hypothesis (working on other projects). The only thing that got out of it were molecules that were really

I worked in a lab doing research based on that amyloid hypothesis (working on other projects). The only thing that got out of it were molecules that were really good at messing up the assays used but had 0 biological effect in vivo. So in the end the lab optimized the protein and cell assays to make them were more sensitive to artifacts. This wasn't made on purpose, just a combination of human and institutional factors that combined as a perfect storm. Several dozens of academic papers were published on that... That's what happens when you have isolated labs in a university that doesn't favor and nurture collaborations but focuses instead on political and economical aspects. Now all the people that took the wrong decisions have either retired or got fancy positions elsewhere.