It’s really complex. For a partial survey of that complexity, see this SSC: https://slatestarcodex.com/2017/06/13/what-is-depression-anyway-the-synapse-hypothes

It’s really complex. For a partial survey of that complexity, see this SSC: https://slatestarcodex.com/2017/06/13/what-is-depression-anyway-the-synapse-hypothesis/ https://slatestarcodex.com/2017/06/13/what-is-depression-any.... Part of the problem in describing/treating this condition is that depression is a huge constellation of overlapping causal mechanisms. You may be describing one set of mechanisms but it’s certainly not the only one.