4 ms·
Think we have known this for a while. For example Wellbutrin (Bupropion) works well for many people and it doesn’t work on serotonin levels at all. In fact it
by roody15 4y ago
Think we have known this for a while. For example Wellbutrin (Bupropion) works well for many people and it doesn’t work on serotonin levels at all. In fact it causes an increase of dopamine uptake in the brain.
Think increasing the dopamine levels causes a variety of changes to complex systems in the brain that are not really fully understood.
SSRi’s also cause changes to underlying systems in the brain that are not as simple as you are “low” on serotonin.
My two cents
- y-c-o-m-b 4y agoI'm on Wellbutrin (lowest dose) and it works great. I have no side effects whatsoever. Been on it since 2019. It's kept my depression in check and even helps with my ADHD a little. They say you can't drink alcohol with it, but I binge drink every weekend (I really love alcohol) with no problems. SSRIs were an absolute train-wreck to be on; they made me angry and violent. I was on them for 10 years and I honestly don't believe it ever helped against depression. If I missed 1 day, I'd get the infamous "brain zaps". It took me about 3 months to taper off the damn things and it was a brutal 3 months. The last one was in October 2012 and I will never take them again. I did not experience any increase in depression either, so that makes a stronger case for them basically be worthless for me.
- ssvss 4y agoHow long did it take for Wellbutrin to work for you. I was on it for 2 months, it didn`t help, so I stopped.
- y-c-o-m-b 4y agoIt only took about a week. It wasn't a massive difference in mood, just a small boost, which is all I needed to get by.
- ffwacom 4y ago>but I binge drink every weekend (I really love alcohol) with no problems this is almost certainly the cause of your 'depression'