3 ms·
I'm not sure what you're suggesting, but SSRIs definitely do change a number of measurable metrics of the serotonin system by prolonging the duration of seroton
by PragmaticPulp 4y ago
I'm not sure what you're suggesting, but SSRIs definitely do change a number of measurable metrics of the serotonin system by prolonging the duration of serotonin in the extrasynaptic space. This is well studied.
The first "S" is for selective, meaning they have minimal affinities beyond the serotonin transporter.
- eurasiantiger 4y agoWhere do you get that from? SSRIs act on SERT and SERT handles reuptake from the synaptic cleft, not from extracellular space which is ”vacuumed” by MAOA/B and COMT.
- zeckalpha 4y agoI don't think we're disagreeing. Increasing duration spent in one place doesn't change the total count of the molecule. SSRIs don't make the body produce more. That's okay, they work by other means.