4 ms·

From a throwaway because of the potential backlash...This paper is pure bull. They did a survey of 30k people and asked them about their experience and then sa

From a throwaway because of the potential backlash...This paper is pure bull. They did a survey of 30k people and asked them about their experience and then said that the vaccine didn't cause anything and that we should trust our institutions. They didn't even have a control (unvaccinated) group! Just 30k vaccinated folks who responded to a survey about whether they perceived more/less bleeding, and such. I'm actually working (as a computational mathematician) with an OBGYN and a few other doctors on a paper on this topic right now. We're using real data and a control and doing real Bayesian stats and all of that. But the tragic thing is, we don't need to get fancy. There's so much signal that the vaccine is bad for women's reproductive health that it really is obvious. I hope we can find an uncaptured journal to get it published in. This paper is pure propaganda that's toeing the line about vaccine safety. It's idea laundering so they can later point to an article in "Science" showing that it's safe. I'm so sad that Science (the journal) as fallen so far and is so captured.

manwe150 4y ago
How bad is it for health? This paper also notes that the virus itself is of great concern foremost, so any conclusion must be in comparison to the alternative (aka the control group): “Studies and anecdotal reports are already demonstrating that menstrual function may be disrupted long term [by the virus], particularly in those with long COVID (32–35)” It seems so many commenters here miss that sentence, and live in a mental world where viruses are mostly benign but healthcare is mostly deadly. Therefore, a statistical control group for such a trial as you describe doing is not an unvaccinated cohort for the same time period, but rather for infinite time. Thus your results will require substantial adjustment for the eventual rates of encountering COVID (and the estimated rates of equivalent adverse effects), since your trial will presumably be of finite duration.
- peter422 4y ago
  “Placebo Effect Accounts for More Than Two-Thirds of COVID-19 Vaccine Adverse Events, Researchers Find” https://www.bidmc.org/about-bidmc/news/2022/01/placebo-effect-contributes-to-covid-19-vaccine-adverse-events https://www.bidmc.org/about-bidmc/news/2022/01/placebo-effec... It seems very unintuitive but when you have these studies without a control they are shockingly biased… not due to anybody’s fault, just human nature.
  - incrudible 4y ago
    Nice. Now do "Long COVID".
- throwaway406382 4y ago
  It is possible to take a finite duration and look at the unvaccinated+covid, unvaccinated+no-covid, vaccinated+covid, vaccinated+no-covid and see differences. And the signals a so large between unvaccinated and vaccinated you don't need much in the way of fancy stats. Also consider that it wasn't until the late 90's that the flu vaccine was approved for pregnant women and they were still worried about it. So we have the original adverse event studies post flu vaccine and compare them to post covid vaccine. You are right, there are lots of confounds and interactions, we are careful to handle that properly. We're a bunch of nerds who don't have a dog in the political fight, we just want to show the data.
  - mrguyorama 4y ago
  - jomjomv 4y ago
    Which vaccine does your research refer to? Can you share?
  - manwe150 4y ago
    Good, that is what I was hoping to hear. Looking forward to seeing it published. Though unvaccinated+no-covid does not exist in steady state, so any signal that includes them cannot be extrapolated into the future. But it is seeming like vaccinated+no-covid won’t exist either in the long term steady-state. So we might eventually be having to deal statistically with considering frequency of infection instead of binary yes/no. Lots of math to consider. Best wishes to you in this.
- incrudible 4y ago
  > It seems so many commenters here miss that sentence, and live in a mental world where viruses are mostly benign but healthcare is mostly deadly. Viruses are indeed mostly benign. Medical malpractice is a leading cause of death. In any case, it is not an either or. This vaccine does not prevent infection, the risk reduction for an otherwise healthy person, especially with the new variants and boosters, has never been established in a scientifically rigorous fashion. Yet, it is being recommended even to healthy children. You can hope and speculate that it has a benefit, but “the science” does not say so.
  - somewhereoutth 4y ago
    Yes the science absolutely does say so - perhaps try to follow it before spreading mis-information.
    - incrudible 4y ago
      Show me the clinical trial that shows a benefit for administration of a Booster, or even just two doses, providing a net benefit for a healthy young person, after accounting for hazards like Myocarditis, with an Omikron infection. It doesn't exist, nor does anyone "in charge" want it to exist, or so it appears. The FDA waved through a trial for children with a sample size of about 1000, almost guaranteeing that a rare side effect like Myocarditis would not show up. That's a clear signal of regulatory capture, if you ask me. The data that does show a benefit generally does not stratify across factors like age and risk factors, or if it does, extremely coarsely. That's, of course, misleading - perhaps intentionally so. In general, the paucity of meaningful data is just staggering.
      - somewhereoutth 4y ago
        https://www.businessinsider.com/cdc-charts-omicron-hospitalization-vaccine-booster-unvaccinated-2022-1 https://www.businessinsider.com/cdc-charts-omicron-hospitali... Over 50s effect of vaccination on hospitalization. If it is protecting older people against hospitalization then we can expect it to protect younger people from severe effects too. Unless you think the over 50s are some sort of frog vs the younger tadpole. Plenty more everywhere. So why would some of us be so vehemently anti-vax? 1) Belief in 'natural'. This has been a common marketing ploy since 'green' became a thing if not before. Of course the world we actually live in is entirely artificial - just as well as our 'natural' lives were nasty, brutish, and short. 2) Attempting to assert 'independence' or 'agency'. Again another marketing ploy, really we have very little agency or independence - however it is useful to make us believe we do and we should exercise it with our credit cards. 3) Attempting to be contrarian or a 'free thinker' in order to impress (ourselves? others?). Much much more humility is required before starting down that path. 4) Ideological/political propaganda/pressure from our peers. Belief systems have a tendency to become pathological when contained within a tightly delimited group. Probably this is a very great danger to our social discourse at present - though whether worse than before is unclear.
jbd28 4y ago
Pretty strong words and claims while providing no data to refute the paper
- throwaway406382 4y ago
  Yes...I'll post the paper to HN when it's live. We're still finalizing analyses and writing the paper and I'm not at liberty to share it yet.
  - bandyaboot 4y ago
    You’re only at liberty to share the conclusion that the vaccine is very dangerous?
fferen 4y ago
Note that this is Science Advances, a much less prestigious journal than Science proper.
belter 4y ago
"Ten thousand report menstrual issues after having corona vaccine" (October 2021) https://www.dutchnews.nl/news/2021/10/ten-thousand-report-menstrual-issues-after-having-corona-vaccine/ https://www.dutchnews.nl/news/2021/10/ten-thousand-report-me... [Dutch Reference]: https://www.lareb.nl/news/veel-meldingen-menstruatiestoornissen-na-coronavaccins https://www.lareb.nl/news/veel-meldingen-menstruatiestoornis...
bandyaboot 4y ago
No actual professional would do something like what you’re doing here. Very hard to believe this is anything but pure bullshit. Edit: it’s pretty sad that there are people who have such an ingrained agenda that they have convinced themselves that, yes, this IS how a professional involved in a scientific public health study behaves.
- throwaway102233 4y ago
  - bandyaboot 4y ago
    It wasn’t clear, but the edit wasn’t in reference to the parent commenter. But now that you mention it, yes, for them I’m leaning toward “agenda” rather than the alternative of “non-existent professional ethical standards”.
tiahura 4y ago
How do you explain the fact that the US birth rate dipped (barely) pre-vaccine and has crept back up post-vaccine? https://www.cdc.gov/nchs/nvss/vsrr/natality-dashboard.htm# https://www.cdc.gov/nchs/nvss/vsrr/natality-dashboard.htm#
- throwaway406382 4y ago
  Well, I'm not a doctor, just someone doing stats for doctors...but I think we're going to start seeing it as we're reaching the 9-month mark from the big push for child-bearing-age vaccination. It's starting to show up in Sweden and (I think) Taiwan, but it's not something I'm really studying. https://boriquagato.substack.com/p/sweden-birthrate-update-may-data https://boriquagato.substack.com/p/sweden-birthrate-update-m...
  - manwe150 4y ago
    Didn’t the 9 month mark (since delta’s effect on vax rates) pass about 3 months ago in the US (referring to parent)? Or what time/mark event are you looking for?
    - throwaway406382 4y ago
      Well, now we're just getting May data and maybe June data. So that would be conceptions starting in August 2021. Here's a really lame screen capture of a visualization I just made with the CDC data. The August time frame is where we're passing 50% of the 25-39 year-olds getting vaccinated. So that would start to show up in the May 2022 birth data. https://pasteboard.co/uhkdWFvhCf9c.png https://pasteboard.co/uhkdWFvhCf9c.png edit: this showed up in my inbox during dinner - more evidence https://igorchudov.substack.com/p/new-data-from-germany-births-and https://igorchudov.substack.com/p/new-data-from-germany-birt...
      - dktokyo 4y ago
        This could just as easily be related to increased infections among young people at this time. You have no reason to pin this specifically on vaccination.
koolba 4y ago
How would you have a control for a study like this when vaccinations were all but mandatory for large swathe of the population? You’re going to give a placebo vaccine and placebo vaccine card?

manwe150 4y ago

How bad is it for health? This paper also notes that the virus itself is of great concern foremost, so any conclusion must be in comparison to the alternative (aka the control group): “Studies and anecdotal reports are already demonstrating that menstrual function may be disrupted long term [by the virus], particularly in those with long COVID (32–35)” It seems so many commenters here miss that sentence, and live in a mental world where viruses are mostly benign but healthcare is mostly deadly. Therefore, a statistical control group for such a trial as you describe doing is not an unvaccinated cohort for the same time period, but rather for infinite time. Thus your results will require substantial adjustment for the eventual rates of encountering COVID (and the estimated rates of equivalent adverse effects), since your trial will presumably be of finite duration.

peter422 4y ago
“Placebo Effect Accounts for More Than Two-Thirds of COVID-19 Vaccine Adverse Events, Researchers Find” https://www.bidmc.org/about-bidmc/news/2022/01/placebo-effect-contributes-to-covid-19-vaccine-adverse-events https://www.bidmc.org/about-bidmc/news/2022/01/placebo-effec... It seems very unintuitive but when you have these studies without a control they are shockingly biased… not due to anybody’s fault, just human nature.
- incrudible 4y ago
  Nice. Now do "Long COVID".
throwaway406382 4y ago
It is possible to take a finite duration and look at the unvaccinated+covid, unvaccinated+no-covid, vaccinated+covid, vaccinated+no-covid and see differences. And the signals a so large between unvaccinated and vaccinated you don't need much in the way of fancy stats. Also consider that it wasn't until the late 90's that the flu vaccine was approved for pregnant women and they were still worried about it. So we have the original adverse event studies post flu vaccine and compare them to post covid vaccine. You are right, there are lots of confounds and interactions, we are careful to handle that properly. We're a bunch of nerds who don't have a dog in the political fight, we just want to show the data.
- mrguyorama 4y ago
- jomjomv 4y ago
  Which vaccine does your research refer to? Can you share?
- manwe150 4y ago
  Good, that is what I was hoping to hear. Looking forward to seeing it published. Though unvaccinated+no-covid does not exist in steady state, so any signal that includes them cannot be extrapolated into the future. But it is seeming like vaccinated+no-covid won’t exist either in the long term steady-state. So we might eventually be having to deal statistically with considering frequency of infection instead of binary yes/no. Lots of math to consider. Best wishes to you in this.
incrudible 4y ago
> It seems so many commenters here miss that sentence, and live in a mental world where viruses are mostly benign but healthcare is mostly deadly. Viruses are indeed mostly benign. Medical malpractice is a leading cause of death. In any case, it is not an either or. This vaccine does not prevent infection, the risk reduction for an otherwise healthy person, especially with the new variants and boosters, has never been established in a scientifically rigorous fashion. Yet, it is being recommended even to healthy children. You can hope and speculate that it has a benefit, but “the science” does not say so.
- somewhereoutth 4y ago
  Yes the science absolutely does say so - perhaps try to follow it before spreading mis-information.
  - incrudible 4y ago
    Show me the clinical trial that shows a benefit for administration of a Booster, or even just two doses, providing a net benefit for a healthy young person, after accounting for hazards like Myocarditis, with an Omikron infection. It doesn't exist, nor does anyone "in charge" want it to exist, or so it appears. The FDA waved through a trial for children with a sample size of about 1000, almost guaranteeing that a rare side effect like Myocarditis would not show up. That's a clear signal of regulatory capture, if you ask me. The data that does show a benefit generally does not stratify across factors like age and risk factors, or if it does, extremely coarsely. That's, of course, misleading - perhaps intentionally so. In general, the paucity of meaningful data is just staggering.
    - somewhereoutth 4y ago
      https://www.businessinsider.com/cdc-charts-omicron-hospitalization-vaccine-booster-unvaccinated-2022-1 https://www.businessinsider.com/cdc-charts-omicron-hospitali... Over 50s effect of vaccination on hospitalization. If it is protecting older people against hospitalization then we can expect it to protect younger people from severe effects too. Unless you think the over 50s are some sort of frog vs the younger tadpole. Plenty more everywhere. So why would some of us be so vehemently anti-vax? 1) Belief in 'natural'. This has been a common marketing ploy since 'green' became a thing if not before. Of course the world we actually live in is entirely artificial - just as well as our 'natural' lives were nasty, brutish, and short. 2) Attempting to assert 'independence' or 'agency'. Again another marketing ploy, really we have very little agency or independence - however it is useful to make us believe we do and we should exercise it with our credit cards. 3) Attempting to be contrarian or a 'free thinker' in order to impress (ourselves? others?). Much much more humility is required before starting down that path. 4) Ideological/political propaganda/pressure from our peers. Belief systems have a tendency to become pathological when contained within a tightly delimited group. Probably this is a very great danger to our social discourse at present - though whether worse than before is unclear.

jbd28 4y ago

Pretty strong words and claims while providing no data to refute the paper

throwaway406382 4y ago
Yes...I'll post the paper to HN when it's live. We're still finalizing analyses and writing the paper and I'm not at liberty to share it yet.
- bandyaboot 4y ago
  You’re only at liberty to share the conclusion that the vaccine is very dangerous?

fferen 4y ago

Note that this is Science Advances, a much less prestigious journal than Science proper.

belter 4y ago

"Ten thousand report menstrual issues after having corona vaccine" (October 2021) https://www.dutchnews.nl/news/2021/10/ten-thousand-report-menstrual-issues-after-having-corona-vaccine/ https://www.dutchnews.nl/news/2021/10/ten-thousand-report-me... [Dutch Reference]: https://www.lareb.nl/news/veel-meldingen-menstruatiestoornissen-na-coronavaccins https://www.lareb.nl/news/veel-meldingen-menstruatiestoornis...

bandyaboot 4y ago

No actual professional would do something like what you’re doing here. Very hard to believe this is anything but pure bullshit. Edit: it’s pretty sad that there are people who have such an ingrained agenda that they have convinced themselves that, yes, this IS how a professional involved in a scientific public health study behaves.

throwaway102233 4y ago
- bandyaboot 4y ago
  It wasn’t clear, but the edit wasn’t in reference to the parent commenter. But now that you mention it, yes, for them I’m leaning toward “agenda” rather than the alternative of “non-existent professional ethical standards”.

tiahura 4y ago

How do you explain the fact that the US birth rate dipped (barely) pre-vaccine and has crept back up post-vaccine? https://www.cdc.gov/nchs/nvss/vsrr/natality-dashboard.htm# https://www.cdc.gov/nchs/nvss/vsrr/natality-dashboard.htm#

throwaway406382 4y ago
Well, I'm not a doctor, just someone doing stats for doctors...but I think we're going to start seeing it as we're reaching the 9-month mark from the big push for child-bearing-age vaccination. It's starting to show up in Sweden and (I think) Taiwan, but it's not something I'm really studying. https://boriquagato.substack.com/p/sweden-birthrate-update-may-data https://boriquagato.substack.com/p/sweden-birthrate-update-m...
- manwe150 4y ago
  Didn’t the 9 month mark (since delta’s effect on vax rates) pass about 3 months ago in the US (referring to parent)? Or what time/mark event are you looking for?
  - throwaway406382 4y ago
    Well, now we're just getting May data and maybe June data. So that would be conceptions starting in August 2021. Here's a really lame screen capture of a visualization I just made with the CDC data. The August time frame is where we're passing 50% of the 25-39 year-olds getting vaccinated. So that would start to show up in the May 2022 birth data. https://pasteboard.co/uhkdWFvhCf9c.png https://pasteboard.co/uhkdWFvhCf9c.png edit: this showed up in my inbox during dinner - more evidence https://igorchudov.substack.com/p/new-data-from-germany-births-and https://igorchudov.substack.com/p/new-data-from-germany-birt...
    - dktokyo 4y ago
      This could just as easily be related to increased infections among young people at this time. You have no reason to pin this specifically on vaccination.

koolba 4y ago

How would you have a control for a study like this when vaccinations were all but mandatory for large swathe of the population? You’re going to give a placebo vaccine and placebo vaccine card?