3 ms·

I have to wonder that the insistence of boosting so often might lead to the inverse effect desensitising the body to the proteins just like what happens when yo

I have to wonder that the insistence of boosting so often might lead to the inverse effect desensitising the body to the proteins just like what happens when you vaccinate against allergies, possibly leading to worse illness than if you did not boost. The weird insistence on anti-body levels is another weird thing, just plainly ignoring immune memory. I suspect that we are not seeing grave illness anymore in most of the population due to the immune naive population being very low and the few people dying now are in the traditional old age and immune compromised categories that also die by other respiratory viruses under similar circumstances. Reading the science so much is fumbling in the blind (over 2 years into this). They are still pushing for under 5s to be vaccinated in some countries even though at the efficacy of the vaccine is less than 40% something that would be considered a failure in any other vaccine development and knowing the groups it he lowest risk group there is. And before you call me anti-vaxer I had two doses of Pfizer and have had covid 3 times.

manwe150 4y ago
Presumably that has not been a primary concern, since other vaccines also have historically had regular boosters and haven’t seen that happen (referring to Tdap, rabies, or flu shots) Flu vaccine has historically also been around 25-50% effective, and is still recommended and paid for by insurance, since the benefit is measured positively to you. So there is some precedent for disappointing numbers still being promoted for their small estimated benefits in net.
- christkv 4y ago
  Sure once a year for flu shots with different strains. This is the exact same protein again and again. Nothing like this has been done before outside of allergy vaccines from what my allergist told me who is to say at the very least skeptical about it.
  - manwe150 4y ago
    Why would it be the same protein used then, if that happened? The booster trials for delta and omicron compared the advantages of changing the protein to using the same shot, and used the same shot because it was observed to work well in trials. Also, again, the tetanus and rabies vaccines have regular boosters, with exactly the same formulation. So what is it they claim hasn’t been done before and why?
    - origin_path 4y ago
      They didn't work well actually. Effectiveness against Omicron of boosters was zero. The regulators and pharma firms did however redefine "work" to mean the generation of antibodies (against the long extinct 2019 strain spike protein). This is illogical and puts the cart before the horse; we only care about antibodies to the extent they stop people getting sick. The reason they had to do this is because the vaccines cause fixation. The body can't tell the different spikes apart, so injection with mRNA coding for Omicron spike leads the body to create (not very effective) antibodies against the original spike from the first round of vaccines. Immune memory seems to lack resolution, or possibly Omicron evolved specifically to confuse it in that way, but whatever the cause is, the body just says "a spike! i know what to do!" and doesn't learn from the new round of adjusted vaccines. Unfortunately this type of so-called biomarker study is now becoming commonplace. They are confusing the means for the end.
    - christkv 4y ago
      The current booster is still the same vaccine as before meaning a lot of people have had up to 4 shots of the same vaccine. The new variant shot is not generally available as far as I know at least in Europe
loonster 4y ago
>I suspect that we are not seeing grave illness anymore in most of the population due to the immune naive population being very low and the few people dying now are in the traditional old age and immune compromised categories that also die by other respiratory viruses under similar circumstances. I suspect part of the reason is hospitals are no longer killing their patients through ineffective protocols. Remember the big shortage of ventilators, and how the government is going to get GM to build them. Then it quietly went away because ventilators were killing patients.

manwe150 4y ago

Presumably that has not been a primary concern, since other vaccines also have historically had regular boosters and haven’t seen that happen (referring to Tdap, rabies, or flu shots) Flu vaccine has historically also been around 25-50% effective, and is still recommended and paid for by insurance, since the benefit is measured positively to you. So there is some precedent for disappointing numbers still being promoted for their small estimated benefits in net.

christkv 4y ago
Sure once a year for flu shots with different strains. This is the exact same protein again and again. Nothing like this has been done before outside of allergy vaccines from what my allergist told me who is to say at the very least skeptical about it.
- manwe150 4y ago
  Why would it be the same protein used then, if that happened? The booster trials for delta and omicron compared the advantages of changing the protein to using the same shot, and used the same shot because it was observed to work well in trials. Also, again, the tetanus and rabies vaccines have regular boosters, with exactly the same formulation. So what is it they claim hasn’t been done before and why?
  - origin_path 4y ago
    They didn't work well actually. Effectiveness against Omicron of boosters was zero. The regulators and pharma firms did however redefine "work" to mean the generation of antibodies (against the long extinct 2019 strain spike protein). This is illogical and puts the cart before the horse; we only care about antibodies to the extent they stop people getting sick. The reason they had to do this is because the vaccines cause fixation. The body can't tell the different spikes apart, so injection with mRNA coding for Omicron spike leads the body to create (not very effective) antibodies against the original spike from the first round of vaccines. Immune memory seems to lack resolution, or possibly Omicron evolved specifically to confuse it in that way, but whatever the cause is, the body just says "a spike! i know what to do!" and doesn't learn from the new round of adjusted vaccines. Unfortunately this type of so-called biomarker study is now becoming commonplace. They are confusing the means for the end.
  - christkv 4y ago
    The current booster is still the same vaccine as before meaning a lot of people have had up to 4 shots of the same vaccine. The new variant shot is not generally available as far as I know at least in Europe

loonster 4y ago

>I suspect that we are not seeing grave illness anymore in most of the population due to the immune naive population being very low and the few people dying now are in the traditional old age and immune compromised categories that also die by other respiratory viruses under similar circumstances. I suspect part of the reason is hospitals are no longer killing their patients through ineffective protocols. Remember the big shortage of ventilators, and how the government is going to get GM to build them. Then it quietly went away because ventilators were killing patients.