For DOM you can get pretty far binding http://google.github.io/incremental-dom/ http://google.github.io/incremental-dom/ to C (it's all just procedure calls).

For DOM you can get pretty far binding http://google.github.io/incremental-dom/ http://google.github.io/incremental-dom/ to C (it's all just procedure calls). But other than that there are OpenGL bindings (eg. in emscripten) and things for audio like SoLoud etc. You can usually put off writing JS for a while.