PipeWire can supply even lower latencies than PulseAudio (approaching jackd or perhaps matching it if mic and speakers run at the same clock and don't need resa

PipeWire can supply even lower latencies than PulseAudio (approaching jackd or perhaps matching it if mic and speakers run at the same clock and don't need resampling), but the only way to fully take advantage of PipeWire offering "zero latency routing and no mixing latency beyond hardware buffers" is to rewrite apps from the PulseAudio API to JACK or native PipeWire, which most browsers (and presumably VoIP software) haven't done.