If you use fertilizers and expect a bumper crop every harvest, eventually the soil gets fucked to a point where amendments to make it viable are too expensive,

If you use fertilizers and expect a bumper crop every harvest, eventually the soil gets fucked to a point where amendments to make it viable are too expensive, getting to a point where the soil loses integrity and is unusable. To keep land arable in the longer term, you need to do crop/usage rotation, no-till farming, etc. Agriculture is fun.