I use PixInsight myself, but you can do a lot on photoshop and a lot of people will take the output of PixInsight to touch up in photoshop. Modern sensors are

I use PixInsight myself, but you can do a lot on photoshop and a lot of people will take the output of PixInsight to touch up in photoshop. Modern sensors are amazingly low noise. 10 years ago, I used to have to calibrate out darks, bias and flats just to remove my sensor noise. Now with modern CMOS sensors, people still do that but it isn't as necessary and you can overcome much of the sensor noise by capturing enough data - and that's where JWST just dominates. THere is nothing impeeding the data causing noise. Shot noise is easily removed by integration, Read noise on modern sensors is almost non existent and easily calibrated out, dark current is extremely low, bias, hot and cold pixels are all things that can be removed with calibration and integration and with space telescopes cosmic rays are probably the most annoying thing but if you stack enough images they integrate right out. But back to photoshop, the final images are just publishing art. I use pixinsight myself for all the heavy lifting, pixel math, integration and calibration but sometimes go out to photoshop for cleanup - especially for web/print.