The already have a good solution for surviving in Zero-G: Exercise. We had people on the ISS stay for a year. I would also imagine the difference between zero

The already have a good solution for surviving in Zero-G: Exercise. We had people on the ISS stay for a year. I would also imagine the difference between zero gravity and little moon gravity to be quiet significant regarding keeping people healthy. Will long extended stays be healthy? No but that is a problem for the far future. I think the focus now should be to get the basic logistics in order. I am sure there would be enough people that would be willing to participate in a mission to Moon even if it meant a shortening of their lifespan. Nothing about the first colonization attempts will be pretty but colonization has never been very pretty in human history to begin with.