49 ms·
VeriSIM seems to be targeting drug discovery, rather than drug testing. I don't think scientists regularly use animal models for drug discovery, if at all, beca
by lofatdairy 4y ago
VeriSIM seems to be targeting drug discovery, rather than drug testing. I don't think scientists regularly use animal models for drug discovery, if at all, because it's really not that efficient (animals aside, you'd have to synthesize a dose of everything you want to try, which is non-trivial). With drug discovery, what you need to do is just shotgun a bunch of molecules and test that they're even bioactive, let alone therapeutic (you don't even need to find all the bioactive molecules, just yield enough for further testing).
For actual testing, there are also microfluidic systems and organ-on-a-chip systems that are a field of active research. I think most researchers are more confident in these systems than in-silico (even though organ-on-a-chip systems are a field of active research and have their own shortcomings) because biological systems are active on several different physiological scales, and simulating all of these is rather rough around the edges to say the least. C elegans and fruit fly simulations are still the target of research, and I think fruit flies aren't simulated accurately from the cellular level (though if anyone knows better let me know). Simulating anything more complicated is likely to require either enormous computational resources as well as actual discovery, since you'd need to first characterize everything before you can simulate it.