Good question! Your brain needs sugar to run, so it's not surprising that a high-fat diet might stress it. Especially in mice. Our livers can produce ketone bo

Good question! Your brain needs sugar to run, so it's not surprising that a high-fat diet might stress it. Especially in mice. Our livers can produce ketone bodies as a replacement for sugar. Can mice? It's also, of course, possible that a ketogenic diet helps counter diabetes while still being less healthy than a better rounded diet would be for someone not diabetic.