> What we need is … What we need is a vaccine that works better. Everything else is just speculation until it’s tested in well-designed trials that test the ri

> What we need is … What we need is a vaccine that works better. Everything else is just speculation until it’s tested in well-designed trials that test the right thing in actual humans. Sure, you may think we need an intranasal vaccine and I may think we need an attenuated-virus vaccine stimulating a T cell response against ORF1ab peptides, but we could both be entirely wrong. Keep in mind that the measles vaccine is injectable and produces excellent durable protection against the airborn measles virus. The chickenpox vaccine is an injected live virus vaccine that appears to provide excellent durable protection against chickenpox, which, while it sure looks like a virus that would be transmitted mainly by shedding from blisters, is apparently also airborn. Meanwhile, a hypothetical intranasal vaccine that raised an awesome IgA response with the same affinity as the the IgG antibodies in people vaccinated with the current mRNA vaccines but did nothing else seems unlikely to be especially effective against BA.4 and BA.5.