Scientists have known about immune compartmentalization and the how to evoke the different types of antibodies since the 1960s (and T-cell residence in 1980s).

Scientists have known about immune compartmentalization and the how to evoke the different types of antibodies since the 1960s (and T-cell residence in 1980s). It just hasn't made it into public messaging about vaccines for aerosol spread viruses until recently because it wasn't a world stage issue. There's no doubt intramuscular vaccination still does help against infection in other immune compartments. It's just not the best at it. This has been shown in large scale studies re: sars-cov-2 from Israel in terms of likelyhood of being infected if someone in your residence gets infected. ref: https://www.science.org/doi/10.1126/science.abl4292 https://www.science.org/doi/10.1126/science.abl4292 "Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel"