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Intramuscular sars-cov-2 vaccines to produce humoral igM and igG antibodies (and body serum resident T cells) based on a genetic sequence from 2+ years ago are

Intramuscular sars-cov-2 vaccines to produce humoral igM and igG antibodies (and body serum resident T cells) based on a genetic sequence from 2+ years ago are now thrown away. That's unfortunate but a 4th dose has limited returns. What we need is intranasal sars-cov-2 vaccine boosters to provide igM and igA antibodies, and more importantly trained tissue resident T cells, in the upper respiratory mucosa immune compartment where igG antibodies do not penetrate. That's where infection starts and replication goes (mostly) unchecked. Even just updating the sequence to reflect current variants while remaining intramuscular only would be okay and that will happen this fall (too late). But if we really want to mitigate spread and mutation to complement the protection from hospitalization intramusculars give we're going to need continued funding for new vaccines.

8note 4y ago
But how do first doses do now? I'm sure there's still plenty of places that haven't gotten access to a first shot yet
- xeromal 4y ago
  The current vaccine effectiveness against infection for either Moderna's, BioNTech/Pfizers, or AstroZeneca's against BA.4/BA.5 is 0-30%.
  - azinman2 4y ago
    What’s more important is hospitalization / severe disease / death, which it seems to be much better at.
doliveira 4y ago
Sad part I remember back in the beginning of the pandemic people mentioning this: we needed intranasal vaccines to properly stomp transmission. Feels like the initial success of Pfizer and Moderna stopped this development
amluto 4y ago
> What we need is … What we need is a vaccine that works better. Everything else is just speculation until it’s tested in well-designed trials that test the right thing in actual humans. Sure, you may think we need an intranasal vaccine and I may think we need an attenuated-virus vaccine stimulating a T cell response against ORF1ab peptides, but we could both be entirely wrong. Keep in mind that the measles vaccine is injectable and produces excellent durable protection against the airborn measles virus. The chickenpox vaccine is an injected live virus vaccine that appears to provide excellent durable protection against chickenpox, which, while it sure looks like a virus that would be transmitted mainly by shedding from blisters, is apparently also airborn. Meanwhile, a hypothetical intranasal vaccine that raised an awesome IgA response with the same affinity as the the IgG antibodies in people vaccinated with the current mRNA vaccines but did nothing else seems unlikely to be especially effective against BA.4 and BA.5.
usrn 4y ago
I think what we need is trust, good faith communication, and actual science (rather than conjecture and bribes.) That's all gone now, possibly for a very long time.

8note 4y ago

But how do first doses do now? I'm sure there's still plenty of places that haven't gotten access to a first shot yet

xeromal 4y ago
The current vaccine effectiveness against infection for either Moderna's, BioNTech/Pfizers, or AstroZeneca's against BA.4/BA.5 is 0-30%.
- azinman2 4y ago
  What’s more important is hospitalization / severe disease / death, which it seems to be much better at.

doliveira 4y ago

Sad part I remember back in the beginning of the pandemic people mentioning this: we needed intranasal vaccines to properly stomp transmission. Feels like the initial success of Pfizer and Moderna stopped this development

amluto 4y ago

> What we need is … What we need is a vaccine that works better. Everything else is just speculation until it’s tested in well-designed trials that test the right thing in actual humans. Sure, you may think we need an intranasal vaccine and I may think we need an attenuated-virus vaccine stimulating a T cell response against ORF1ab peptides, but we could both be entirely wrong. Keep in mind that the measles vaccine is injectable and produces excellent durable protection against the airborn measles virus. The chickenpox vaccine is an injected live virus vaccine that appears to provide excellent durable protection against chickenpox, which, while it sure looks like a virus that would be transmitted mainly by shedding from blisters, is apparently also airborn. Meanwhile, a hypothetical intranasal vaccine that raised an awesome IgA response with the same affinity as the the IgG antibodies in people vaccinated with the current mRNA vaccines but did nothing else seems unlikely to be especially effective against BA.4 and BA.5.

usrn 4y ago

I think what we need is trust, good faith communication, and actual science (rather than conjecture and bribes.) That's all gone now, possibly for a very long time.