IME Lion's Mane complements caffeine quite nicely. It largely eliminates any withdrawal symptoms after cessation, and noticeably takes the edge off when taking

IME Lion's Mane complements caffeine quite nicely. It largely eliminates any withdrawal symptoms after cessation, and noticeably takes the edge off when taking large caffeine doses. Otherwise it seems like a placebo supplement. But I've never tried mixing it with psilocybin.