4 ms·

> there are medications better than cannabis for anxiety and depression. But no one talks about them. Could you maybe name them? Would be awesome :)

symlinkk 4y ago
+1, I need help.
jotm 4y ago
I've become reluctant to do it since many people can't properly administer them and/or fall into addiction. Then again, it happens with cannabis, too. But eh, whatever, you're responsible for yourself. For me, gabapentinoids and gabaergics work great. Pregabalin, Gabapentin, Sodium Oxybate are what I have experimented with and found to be good. Currently on Pregabalin 2x150mg morning+evening. Each dose lasts 6-7 hours (and lingers for much longer, 24-48 hours). I'd recommend starting with 75mg, only on empty stomach. Effects start after 1-2 hours, if you don't feel anything, up the dose. Don't take too much, I tried 300-450mg in one dose, was too stupefying. Quitting is easy by tapering down over a week. May have 1-2 days of bad sleep or insomnia. Minimized anxiety, suicidal thoughts gone, and it even mixes well with most stimulants (for ADHD). Pretty much the same for Gabapentin, which was great, better than pregabalin (more energy and creativity), until I quit it for ~6 months and now I have some sort of permanent tolerance. It's strange. Sodium Oxybate (aka GHB!) is also great, easier to get but dosing is difficult, it's short lasting and has a big impact on sleep (forced me into biphasic sleep, which is actually how narcoleptics take it), can't fall asleep without it, but it's great quality sleep after ~3 weeks). Big danger of addiction, even though quitting is easy by tapering down over a week. Basically you need more than 12 hours between after the last dose. Or if you fall into a 24/7 trap (taking it every 1-3 hours), lower the dosage every day. Much harder than it sounds so just never take it more than 3-4 times a day and never more than 3-4 grams at a time. Would not recommend it unless you're really good at self-restraint and/or quitting drugs. Quitting an a-pvp binge was easier than sodium oxybate. There's also benzodiazepines and phenibut that I stay clear of (they act partially or fully on GABA-A, way more dangerous/addictive than those that act on GABA-B), and baclofen that I haven't tried due to unavailability. They all have quite different effects and you need to find a right dosage/schedule. Gotta see what works best for you. To put it in simple terms, they're mostly like alcohol without the negative effects. I have to say I've been a long time functional alcoholic (over a decade of near daily use), so either my brain craves something for GABA receptors or I've screwed it up and now this stuff works. Still, any of them are less stupefying than cannabis (and at higher dosages close to it in relaxation effects) and have none of the occasional negative effects like paranoia. Also, I use tizanidine to knock myself to sleep when quitting various stuff. But holy shit, please for the love of everything learn to use medication responsibly, learn to quit them and not fall into abuse, because withdrawal can be ugly.

symlinkk 4y ago

+1, I need help.

jotm 4y ago

I've become reluctant to do it since many people can't properly administer them and/or fall into addiction. Then again, it happens with cannabis, too. But eh, whatever, you're responsible for yourself. For me, gabapentinoids and gabaergics work great. Pregabalin, Gabapentin, Sodium Oxybate are what I have experimented with and found to be good. Currently on Pregabalin 2x150mg morning+evening. Each dose lasts 6-7 hours (and lingers for much longer, 24-48 hours). I'd recommend starting with 75mg, only on empty stomach. Effects start after 1-2 hours, if you don't feel anything, up the dose. Don't take too much, I tried 300-450mg in one dose, was too stupefying. Quitting is easy by tapering down over a week. May have 1-2 days of bad sleep or insomnia. Minimized anxiety, suicidal thoughts gone, and it even mixes well with most stimulants (for ADHD). Pretty much the same for Gabapentin, which was great, better than pregabalin (more energy and creativity), until I quit it for ~6 months and now I have some sort of permanent tolerance. It's strange. Sodium Oxybate (aka GHB!) is also great, easier to get but dosing is difficult, it's short lasting and has a big impact on sleep (forced me into biphasic sleep, which is actually how narcoleptics take it), can't fall asleep without it, but it's great quality sleep after ~3 weeks). Big danger of addiction, even though quitting is easy by tapering down over a week. Basically you need more than 12 hours between after the last dose. Or if you fall into a 24/7 trap (taking it every 1-3 hours), lower the dosage every day. Much harder than it sounds so just never take it more than 3-4 times a day and never more than 3-4 grams at a time. Would not recommend it unless you're really good at self-restraint and/or quitting drugs. Quitting an a-pvp binge was easier than sodium oxybate. There's also benzodiazepines and phenibut that I stay clear of (they act partially or fully on GABA-A, way more dangerous/addictive than those that act on GABA-B), and baclofen that I haven't tried due to unavailability. They all have quite different effects and you need to find a right dosage/schedule. Gotta see what works best for you. To put it in simple terms, they're mostly like alcohol without the negative effects. I have to say I've been a long time functional alcoholic (over a decade of near daily use), so either my brain craves something for GABA receptors or I've screwed it up and now this stuff works. Still, any of them are less stupefying than cannabis (and at higher dosages close to it in relaxation effects) and have none of the occasional negative effects like paranoia. Also, I use tizanidine to knock myself to sleep when quitting various stuff. But holy shit, please for the love of everything learn to use medication responsibly, learn to quit them and not fall into abuse, because withdrawal can be ugly.