Indole-3-Propionic Acid (IPA) is one of the strongest antioxidants in the body and is a critical marker of a healthy gut microbiome. IPA plays a crucial role in

Indole-3-Propionic Acid (IPA) is one of the strongest antioxidants in the body and is a critical marker of a healthy gut microbiome. IPA plays a crucial role in maintaining a healthy gut. It [1] strengthens the tight cellular junctions of the intestinal wall and [2] acts as a potent neuroprotective agent that inhibits beta-amyloid fibril formation, important for brain health. The bacteria Clostridium Sporogenes produce IPA from the amino acid tryptophan. [1] can help with sensitivities to dairy, gluten, eggs, and soy, and feeling unwell after most meals, related to food particles “leaking” through the intestinal cell wall and triggering an immune response. IPA helps prevent that leakage. IPA production depends on the health of the gut microbiome. Including fermented foods like kimchi, sauerkraut, kefir, yogurt, miso, fermented pickles, and fermented bean curd several times per week may benefit the gut microbiome and increase IPA production. Adequate fiber in the diet is also important for maintaining a healthy gut. Examples of fiber-rich foods include vegetables, fruits, whole grains, and sprouted beans and legumes. Refer to the fiber recommendation in the client’s report for a full list of fiber-rich foods. The fiber in these items is a food source for specific bacteria in your gut, and it assists in the production of short-chain fatty acids (SCFA). As bacteria in the gut ferment dietary fiber, short-chain fatty acids are produced. Short-chain fatty acids, like butyrate, are important for a variety of health processes including immune function, digestive health, and weight maintenance. To support IPA levels, Ixcela recommends consuming sprouted seeds (e.g., chickpeas, mung beans, and black beans) at least 3 times per week. Sprouts can often be found in the produce section of the grocery store. Avoiding foods that are detrimental to the gut is important for maintaining optimal IPA levels. Foods to avoid include refined carbohydrates, simple sugars, and omega-6 oils (vegetable or nut oils). Pre-peer reviewed report free here: researchgate.net/publication/347663867_The_intermittent_fasting-dependent_gut_microbial_metabolite_indole-3_propionate_promotes_nerve_regeneration_and_recovery_after_injury "The stress—protective activity of adaptogens was associated with regulation of homeostasis via several mechanisms of action, which was linked with the hypothalamic-pituitary-adrenal axis and the regulation of key mediators of stress response" Source: ncbi.nlm.nih.gov/pmc/articles/PMC3991026/