I am not qualified to comment this article, and my feeling as an amateur in neurodegenerative diseases is that indeed we are making artificial categorization by

I am not qualified to comment this article, and my feeling as an amateur in neurodegenerative diseases is that indeed we are making artificial categorization by seperating Alzheimer's disease from Parkinson, Huntington, etc... but : "The new work, ..., is the first attempt to quantify how much protein aggregation occurs throughout the body during the natural aging of a vertebrate animal — in this case, a very short-lived fish My point is that there are already many studies that were made on humans that shown aging patients have up to four neurodegenerative comorbidities. And for example TDP-43 protein is found in 95% of ALS, some form of Alzheimer such as LATE, FTD, 25% of Parkinson disease cases. Same for other proteins like alpha-synuclein, Tau protein, etc. There are even names for those families of diseases that involve aggregated proteins: Tauopathies, synucleinopathies, amyloidosis, apolipoprotein, aggregation of superoxide dismutase-1 (SOD1), polyglutamine, and TAR DNA-binding protein-43 (TDP-43). There is a long list of diseases linked to protein aggregation on Wikipedia: https://en.wikipedia.org/wiki/Proteinopathy https://en.wikipedia.org/wiki/Proteinopathy So as we have ample evidence on humans that protein aggregation (intra or extra cellular) is a problem for the elderly, why do we need a study on killifish?