Without knowing the mechanism of resistance, you wouldn’t risk giving the patient more of a drug. Many resistance mechanisms remove or block the binding pocket

Without knowing the mechanism of resistance, you wouldn’t risk giving the patient more of a drug. Many resistance mechanisms remove or block the binding pocket drugs bind to. In those cases, adding more frequent dosing wouldn’t be helpful. You might have tried something like this first in a mouse model too. But using a simulation to discover the resistance mechanism can be a much faster way to get your answer (and justify the expense of a mouse study). This study is quite exciting to see.