A lot of the literature suggests that it boosts the effects of chemotherapy. However chemotherapy damages host cells as well. It's unclear if melatonin promotes

A lot of the literature suggests that it boosts the effects of chemotherapy. However chemotherapy damages host cells as well. It's unclear if melatonin promotes sparing of healthy cells that are dividing or simply boosts the effect of chemo everywhere. REVIEWS: Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412427/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412427/ The melatonin immunomodulatory actions in radiotherapy https://pubmed.ncbi.nlm.nih.gov/28510090/ https://pubmed.ncbi.nlm.nih.gov/28510090/ Usefulness of melatonin as complementary to chemotherapeutic agents at different stages of the angiogenic process https://www.nature.com/articles/s41598-020-61622-x https://www.nature.com/articles/s41598-020-61622-x Role of melatonin in cancer treatment https://pubmed.ncbi.nlm.nih.gov/22753734/ https://pubmed.ncbi.nlm.nih.gov/22753734/ Melatonin, a natural programmed cell death inducer in cancer https://pubmed.ncbi.nlm.nih.gov/22612707/ https://pubmed.ncbi.nlm.nih.gov/22612707/ Cancer metastasis: Mechanisms of inhibition by melatonin https://pubmed.ncbi.nlm.nih.gov/27706852/ https://pubmed.ncbi.nlm.nih.gov/27706852/ Melatonin and its ubiquitous anticancer effects https://pubmed.ncbi.nlm.nih.gov/31451998/ https://pubmed.ncbi.nlm.nih.gov/31451998/ PRIMARY LIT: Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis https://pubmed.ncbi.nlm.nih.gov/31970423/ https://pubmed.ncbi.nlm.nih.gov/31970423/ RNA-Seq transcriptome analysis shows anti-tumor actions of melatonin in a breast cancer xenograft model https://pubmed.ncbi.nlm.nih.gov/30700756/ https://pubmed.ncbi.nlm.nih.gov/30700756/ Effect of melatonin on T/B cell activation and immune regulation in pinealectomy mice https://www.sciencedirect.com/science/article/pii/S0024320519311191 https://www.sciencedirect.com/science/article/pii/S002432051... Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats https://pubmed.ncbi.nlm.nih.gov/14672618/ https://pubmed.ncbi.nlm.nih.gov/14672618/ *This is significant because one of the side effects of chemotherapy is increased NFkB, which can induce to tumor growth/resistance* Melatonin-mediated downregulation of thymidylate synthase as a novel mechanism for overcoming 5-fluorouracil associated chemoresistance in colorectal cancer cells https://academic.oup.com/carcin/article/40/3/422/5257709 https://academic.oup.com/carcin/article/40/3/422/5257709 Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway https://www.nature.com/articles/cddis2016330 https://www.nature.com/articles/cddis2016330 Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823085/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823085/