https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123278 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123278 >> Melatonin exhibited various mechanisms to restrain

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123278 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123278 >> Melatonin exhibited various mechanisms to restrain metastasis, such as modulation of cell–cell and cell–matrix interaction, extracellular matrix remodeling by matrix metalloproteinases, readjustment of the cytoskeleton, epithelial-mesenchymal transition, and angiogenesis [127]. A recent study reported that the overexpression of the ADAMTS family in renal cell carcinoma was suppressed by melatonin via amplifying of miR-let-7f/miR-181d and reducing protein stability. It is of note that ADAMTS, a disintegrin, and metalloprotease with thrombospondin motifs family, thought to have an impact on cell metastasis and developing of cancer stages. Note: >> Melatonin has short plasma half-life, variable oral absorption, and low variable bioavailability that could be due to extensive first pass metabolism [327], in addition to its poor solubility and stability [328]. Therefore, conventional oral dosage forms (immediate release) are unsuitable candidates for melatonin delivery.